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This book explores the diverse capabilities of optical probes and presents various approaches used to design, develop, and implement these powerful and versatile tools. It examines the use of optical probes to detect and track numerous molecular processes in living cells, including GTPase and kinase activities, metabolic signals, RNA, and histone modifications. The book also covers sophisticated imaging techniques and equipment used to visualize and track optical probes and discusses emerging techniques that are expanding optical probe-based approaches into new biological frontiers.

Produktbeschreibung
This book explores the diverse capabilities of optical probes and presents various approaches used to design, develop, and implement these powerful and versatile tools. It examines the use of optical probes to detect and track numerous molecular processes in living cells, including GTPase and kinase activities, metabolic signals, RNA, and histone modifications. The book also covers sophisticated imaging techniques and equipment used to visualize and track optical probes and discusses emerging techniques that are expanding optical probe-based approaches into new biological frontiers.

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Autorenporträt
Dr. Jin Zhang is a professor of pharmacology, neuroscience, and oncology in the Johns Hopkins University School of Medicine with a joint appointment in the Department of Chemical and Biomolecular Engineering in the Johns Hopkins University Whiting School of Engineering. She has received the American Heart Association National Scientist Development Award, the Biophysical Society Margaret Oakley Dayhoff Award, the National Institutes of Health Director's Pioneer Award, the American Society for Pharmacology and Experimental Therapeutics John J. Abel Award in Pharmacology, and the American Chemical Society Pfizer Award in Enzyme Chemistry. She was elected a fellow of the American Association for the Advancement of Science (AAAS) in 2014. Dr. Sohum Mehta is a postdoctoral fellow at the Johns Hopkins University School of Medicine, where he is using genetically encoded biosensors to investigate the spatiotemporal mechanisms of calcineurin in living cells and developing novel genetically encoded tools to study intracellular signaling. Dr. Carsten Schultz is a senior scientist at the European Molecular Biology Laboratory in Heidelberg, Germany. He is a member of the German Center for Lung Research. His research focuses on the manipulation and visualization of intracellular signaling networks, with a strong emphasis on lipid and membrane signaling as well as the use of optical probes in translational research. He has received the Heidelberg Molecular Life Science Award and the MRN Innovation Award.