Organoselenium Compounds in Biology and Medicine (eBook, ePUB)

Synthesis, Biological and Therapeutic Treatments
Redaktion: Jain, Vimal Kumar; Priyadarsini, K Indira

• Format: ePub

Produktbeschreibung

Organoselenium shows incredible promise in medicine, particularly cancer therapy. This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications.
Divided into three sections, the first section describes synthetic advances in bioactive selenium compounds, revealing how organoselenium compound toxicity, redox properties and specificity can be further tuned. The second section explains the biophysics and biochemistry of organoselenium compounds, as well as selenoproteins. The final section closes with several chapters devoted to therapeutic and medicinal applications of organoselenium compounds, covering radioprotectors, anticancer agents and antioxidant behaviour.
With contributions from leading global experts, this book covers recent advances in the field and is an ideal reference for those researching organoselenium compounds.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 457
• Erscheinungstermin: 26. September 2017
• Englisch
• ISBN-13: 9781788012232
• Artikelnr.: 49986398

Inhaltsangabe

An overview of organoselenium chemistry: From fundamentals to Synthesis;
Looking Beyond the traditional Idea of Glutathione Peroxidase Mimics as
Antioxidants; Synthesis of organoselenium compounds with potential
biological activities; The Relevant Chemistry of Imidazoline-2-selone
Donors with potential Biological Applications; Organoselenium cations:
Structures, reactivity and applications; Organoselenium flurophores for
probing ROS and heavy metals; Non-bonded selenium...heteroatom interactions
in selenoenzymeglutathioneperoxidase (GPx) and mimics; Carbohydrate-derived
Organoselenium Compounds: Synthesis and Application in the Structural
Analysis of Biomolecules; Reaction of Selenium compounds with reactive
oxygen species and the controlof oxidative stress; Reactive selenium
species: Redox modulation, antioxidant, antimicrobial and anticancer
activities; Ebselen and thioredoxin systems in human health, disease and
therapeutic potential; History and development of selenium based
radioprotectors: Distinction between inorganic vs. organic forms;
Toxicology and anticancer activity of synthetic organoselenium compounds;
Metabolism of selenium/selenocystine and their roles in the prevention and
treatment of human cancer; Organoselenium compounds as cancer therapeutic
agents; Cancer prevention by different forms of selenium