Pain Therapeutics (eBook, PDF)

Current and Future Treatment Paradigms
Redaktion: Allerton, Charlotte

• Format: PDF

Produktbeschreibung

This book presents a contemporary review of the field of Pain Therapeutics, including the historical medicines which still dominate standard of care treatments, as well as the new mechanisms and combinations/reformulations that have dominated the regulatory approvals over the last decade. In addition this book provides a deep review of the key biological mechanisms currently under investigation for their utility into the treatment of pain, such as ion channels, opiates and others.

Additional discussion highlights the current challenges of pain research, covering a range of topics from difficulties in identifying new targets from pre-clinical models to the current regulatory and commercial challenges. This background sets the scene for recent scientific changes in pain research, such as the drive for genetic validation of targets and the derivation of human cell platforms from stem cells. Finally the book covers the discovery and development stories for two pain products approved in the last decade. These case studies for Lyrica and the Butrans patch, give insight into the discovery and development challenges and successes for both an oral and non-oral product.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 426
• Erscheinungstermin: 4. November 2013
• Englisch
• ISBN-13: 9781849737715
• Artikelnr.: 44763820

Inhaltsangabe

The Disease of Pain and Current Market Trends
Oral Opiods
Anti-inflammatory drugs
Ion Channel Modulators
Neurotransmitters and Other Non-Opiate Central Mechanisms
Biotherapeutics for the Treatment of Pain
Peptide Therapeutics from Venomous Creatures
Non Oral Treatments for Pain
Affective and Cognitive Modulation of Pain
Pain Management Companies
Enabling Next Generation Pain Therapeutics through Precision Medicine
Case study:-Discovery and Development of Pregabalin
Case Study:-Discovery and Development of the Butrans Patch