Juan Domínguez-Bendala

Pancreatic Stem Cells (eBook, PDF)

• Format: PDF

Produktbeschreibung

The aim of Pancreatic Stem Cells is to provide a broad overview of an intriguing model of organogenesis (the development of the pancreas) from the perspective of stem cell research. The tangible prospect of devising effective cell therapies for type I diabetes -a disease thus far considered incurable- has stoked a widespread interest in harnessing our knowledge on the basic biology behind the development of this organ. This text is conceived as an all-encompassing guide to explore the many aspects of "regenerative therapies" for the endocrine pancreas, from adult and embryonic stem cells to endogenous regeneration and transdifferentiation. All these themes are built upon an up-to-date discussion on pancreatic ontogeny, which provides a solid background for both basic scientists and health professionals.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 154
• Erscheinungstermin: 10. Februar 2012
• Englisch
• ISBN-13: 9781607611325
• Artikelnr.: 37337951

Inhaltsangabe

1: Preface. Importance of the subject in the context of type I diabetes. 2: The pancreas. 3: Pancreatic development. 4: Pancreatic regeneration. 1. Models of regeneration. 2. Stem cells vs. beta cell replication. 5: Stem cell differentiation: general approaches. 1. Recapitulation of pancreatic development. 2. Signal-driven strategies. 3. Gene transfer and protein transduction. 4. Physiological variables. 6: Embryonic stem cells and pancreatic differentiation. 7: Adult stem cells and pancreatic differentiation. 1. Bone marrow. 2. Umbilical cord. 3. Ductal and acinar cells. 4. Mesenchymal stem cells and de-differentiation. 8: Transdifferentiation. 9: Remaining challenges and clinical perspectives.

Rezensionen

From the reviews:

"There are 69 instructive pictures showing the schemes of individual processes and 787 selected up to date references. There are very useful several insertion explaining individual special terms by a simple and instructive way. This small and valuable book containing a number of up to date and prospective information ... of great value not only for those who are directly involved in diabetes and related problems, but for all those who like to understand the medicine of the future, including medical students." (Endocrine Regulations, 2009)

"Part of the series Stem Cell Biology and regenerative Medicine, this book discusses a field of great interest at present. ... With 787 references. For research diabetologists." (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010)