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PATHOGENESIS OF BACTERIAL INFECTIONS IN ANIMALS Comprehensive review of the major bacterial pathogens of animals, focusing on the current understanding of how they cause disease Pathogenesis of Bacterial Infections in Animals, Fifth Edition is a specialist reference that provides a comprehensive review of bacterial pathogens in animals and their complex interplay with disease processes, offering a complete understanding of how bacteria cause disease in animals. It covers the many recent advances in the field including the newest taxonomies. In this revised and long anticipated fifth edition,…mehr
PATHOGENESIS OF BACTERIAL INFECTIONS IN ANIMALS Comprehensive review of the major bacterial pathogens of animals, focusing on the current understanding of how they cause disease Pathogenesis of Bacterial Infections in Animals, Fifth Edition is a specialist reference that provides a comprehensive review of bacterial pathogens in animals and their complex interplay with disease processes, offering a complete understanding of how bacteria cause disease in animals. It covers the many recent advances in the field including the newest taxonomies. In this revised and long anticipated fifth edition, additional introductory chapters have been added to set the material in context, and more figures added to integrate and improve understanding and comprehension throughout the text. A companion website presents the figures from the book in PowerPoint and references. This detailed reference includes novel approaches to controlling bacterial pathogens in the light of growing concerns about antimicrobial resistance, with more than 70 expert authors sharing their wisdom on the topic. While molecular pathogenesis is a major aspect in almost every chapter, the authors have been careful to place pathogens in their broader context. Pathogenesis of Bacterial Infections in Animals, Fifth Edition also contains information on: * Themes in bacterial pathogenesis, covering the basic elements of pathogenesis, concepts of virulence, host-pathogen interactions and communication, and pathogenesis in the post-genomic era * Evolution of bacterial pathogens, covering what they are and how they emerge, along with sources of genetic diversity, population structure, and genome plasticity * Understanding of pathogenesis through pathogenomics and bioinformatics, including how mutations generate pathogen diversity, and an overview of genome sequencing technologies * Subversion of the immune response by bacterial pathogens, covering subversion of both innate responses and adaptive immunity Pathogenesis of Bacterial Infections in Animals, Fifth Edition is an essential resource for graduate students in veterinary medicine and animal science, and for veterinary microbiologists, pathologists, infectious disease experts, and others interested in bacterial disease. It is the only book to cover this topic to this depth through the wealth of insight of dozens of qualified and practicing professionals.
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John F. Prescott is University Professor Emeritus at the University of Guelph, in Guelph, Ontario, Canada. Janet I. MacInnes is Professor Emerita at the University of Guelph in Guelph, Ontario, Canada. Filip Van Immerseel is Professor at Ghent University in Merelbeke, Belgium. John D. Boyce is Associate Professor at Monash Biomedicine Discovery Institute, Monash University, in Clayton, Victoria, Australia. Andrew N. Rycroft is Professor at the Royal Veterinary College, in Hatfield, Hertfordshire, United Kingdom. José A. Vázquez-Boland is Professor at the University of Edinburgh in Edinburgh, United Kingdom.
Inhaltsangabe
Preface xv
List of Contributors xvii
About the Companion Website xxv
1 Themes in Bacterial Pathogenesis 1 John F. Prescott
Introduction 1
The Basic Elements of Bacterial Pathogenesis 1
Concepts of Bacterial Virulence are Being Refined 5
Host-Pathogen Communications are Critical 9
Pathogenesis in the Post-Genomic Era 11
Gaps in Knowledge and Anticipated Directions 13
References 13
2 Evolution of Bacterial Pathogens 15 Patrick Boerlin
What are Pathogens and How Do They Emerge? 15
Bacterial Fitness and Virulence 17
Sources of Genetic Diversity, Population Structure, and Genome Plasticity 18
Pathogenicity Islands 20
Bacteriophages and Their Role in Pathogen Evolution and Virulence 22
Examples of Virulence Evolution 23
Gaps in Knowledge and Anticipated Directions 27
References 28
3 Understanding Pathogenesis Through Pathogenomics and Bioinformatics 32 Gregorio Iraola and John D. Boyce
Introduction 32
How Mutations Generate Bacterial Diversity 34
Genome Sequencing Technologies 36
Genome Assembly 38
Gene Prediction and Annotation 39
Defining Prokaryotic Species from Genomes 41
The Pangenome Concept, Reconstruction, and Comparative Analyses 41
Phylogenomics and Genome-Wide Association Studies 42
Functional Genomics for Understanding Host-Pathogen Interactions 44
Reverse Vaccinology 48
Gaps in Knowledge and Anticipated Directions 51
References 52
4 Experimental Approaches to Understanding Pathogenesis 57 Francesca L. Short and Janet I. MacInnes
Introduction 57
Testing Koch's Postulates 57
Virulence Factors and Main Steps in Pathogenesis 58
Molecular Koch's Postulates 60
Refining Animal Usage 60
Experimental Approaches for Virulence Factor Discovery and Validation 62
Approaches for Virulence Factor Discovery 63
Gene Disruption Approaches for Virulence Factor Discovery 71
Bringing It All Together: Validation and Further Characterization of Virulence Factors 73
Two Stories of Virulence Factor Discovery and Characterization: Pasteurella multocida Capsule, and Mycoplasma bovis Adhesins 74
Gaps in Knowledge and Anticipated Directions 75
References 76
5 Subversion of the Immune Response by Bacterial Pathogens 79 Douglas C. Hodgins, Raveendra R. Kulkarni, and Patricia E. Shewen
Introduction 79
Subversion of Innate Responses 80
Subversion of Adaptive Immunity 85
Manipulation of Cell Fate 88
Non-Coding RNA and Host-Pathogen Interactions 91
Epigenetic and Genetic Modulation 92
Gaps in Knowledge and Anticipated Directions 94
References 94
6 Chinks in the Armor 99 Allison C. Leonard, Celine Stoica, and Georgina Cox
Introduction 99
Virulence Factors: Pathogenesis-Based Targets to Combat Bacterial Pathogens 99
Targeting Bacterial Host Cell Adhesion and Biofilm Formation 100
Quorum Sensing Inhibition 104
Interfering with Two-Component Regulatory Systems 105
Inhibiting Bacterial Motility 106
Toxin Neutralization 107
Inhibitors of Bacterial Secretion Systems 107
Targeting Nutrient Acquisition: Starving the Pathogen 110
Antivirulence Phage Therapy 111
Bacterial Drug Efflux Pumps as Pathogenesis-Based Antibacterial Targets 112
1 Themes in Bacterial Pathogenesis 1 John F. Prescott
Introduction 1
The Basic Elements of Bacterial Pathogenesis 1
Concepts of Bacterial Virulence are Being Refined 5
Host-Pathogen Communications are Critical 9
Pathogenesis in the Post-Genomic Era 11
Gaps in Knowledge and Anticipated Directions 13
References 13
2 Evolution of Bacterial Pathogens 15 Patrick Boerlin
What are Pathogens and How Do They Emerge? 15
Bacterial Fitness and Virulence 17
Sources of Genetic Diversity, Population Structure, and Genome Plasticity 18
Pathogenicity Islands 20
Bacteriophages and Their Role in Pathogen Evolution and Virulence 22
Examples of Virulence Evolution 23
Gaps in Knowledge and Anticipated Directions 27
References 28
3 Understanding Pathogenesis Through Pathogenomics and Bioinformatics 32 Gregorio Iraola and John D. Boyce
Introduction 32
How Mutations Generate Bacterial Diversity 34
Genome Sequencing Technologies 36
Genome Assembly 38
Gene Prediction and Annotation 39
Defining Prokaryotic Species from Genomes 41
The Pangenome Concept, Reconstruction, and Comparative Analyses 41
Phylogenomics and Genome-Wide Association Studies 42
Functional Genomics for Understanding Host-Pathogen Interactions 44
Reverse Vaccinology 48
Gaps in Knowledge and Anticipated Directions 51
References 52
4 Experimental Approaches to Understanding Pathogenesis 57 Francesca L. Short and Janet I. MacInnes
Introduction 57
Testing Koch's Postulates 57
Virulence Factors and Main Steps in Pathogenesis 58
Molecular Koch's Postulates 60
Refining Animal Usage 60
Experimental Approaches for Virulence Factor Discovery and Validation 62
Approaches for Virulence Factor Discovery 63
Gene Disruption Approaches for Virulence Factor Discovery 71
Bringing It All Together: Validation and Further Characterization of Virulence Factors 73
Two Stories of Virulence Factor Discovery and Characterization: Pasteurella multocida Capsule, and Mycoplasma bovis Adhesins 74
Gaps in Knowledge and Anticipated Directions 75
References 76
5 Subversion of the Immune Response by Bacterial Pathogens 79 Douglas C. Hodgins, Raveendra R. Kulkarni, and Patricia E. Shewen
Introduction 79
Subversion of Innate Responses 80
Subversion of Adaptive Immunity 85
Manipulation of Cell Fate 88
Non-Coding RNA and Host-Pathogen Interactions 91
Epigenetic and Genetic Modulation 92
Gaps in Knowledge and Anticipated Directions 94
References 94
6 Chinks in the Armor 99 Allison C. Leonard, Celine Stoica, and Georgina Cox
Introduction 99
Virulence Factors: Pathogenesis-Based Targets to Combat Bacterial Pathogens 99
Targeting Bacterial Host Cell Adhesion and Biofilm Formation 100
Quorum Sensing Inhibition 104
Interfering with Two-Component Regulatory Systems 105
Inhibiting Bacterial Motility 106
Toxin Neutralization 107
Inhibitors of Bacterial Secretion Systems 107
Targeting Nutrient Acquisition: Starving the Pathogen 110
Antivirulence Phage Therapy 111
Bacterial Drug Efflux Pumps as Pathogenesis-Based Antibacterial Targets 112
Gaps in Knowledge and Anticipated Directions 112
Rezensionen
"The book is well-produced and a useful update on bacterial pathogenesis from a genomics standpoint. It belongs in the diagnostic laboratory, and not just on the bacteriologist's shelf." - Journal of Veterinary Diagnostic Investigation, 2023, Vol. 35(2) 217-218
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