Patient-Derived Xenograft Models of Human Cancer (eBook, PDF)

Redaktion: Wang, Yuzhuo; Gout, Peter W.; Lin, Dong

• Format: PDF

Produktbeschreibung

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text.

Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current statusof the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.

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Produktdetails

• Verlag: Springer Nature Switzerland
• Seitenzahl: 204
• Erscheinungstermin: 27. Juni 2017
• Englisch
• ISBN-13: 9783319558257
• Artikelnr.: 53059797

Autorenporträt

Yuzhuo Wang, PhD Director, Living Tumor Laboratory Distinguished Scientist, BC Cancer Agency Senior Scientist, Vancouver Prostate Centre Professor, University of British Columbia 675 West 10th Avenue, Room 3.122 Vancouver, BC, Canada V5Z 1L3 Dong Lin, PhD, MD Research Pathologist, Living Tumor Laboratory

Inhaltsangabe

Introduction.- History and Evolution of PDX Cancer Models.- Establishment and Characterization of PDX Models.- Methods of Generating PDX Models.- Fidelity and Stability of PDX Models.- Applications of PDX Models.- Studies of Cancer Heterogeneity.- PDX and Cancer Stem Cells.- Modeling Cancer Metastasis.- Modeling Drug Resistance.- PDX and Biomarker Development.- PDX and Preclinical Drug Screening.- Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine.- Epilogue.- Future Perspective.

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