Moritz Wolf (Eidgenossische Technische Hochschule Zurich), Jean-Marc Bielser, Massimo Morbidelli (Eidgenossische Technische Hochschule Zurich)

Perfusion Cell Culture Processes for Biopharmaceuticals (eBook, PDF)

Process Development, Design, and Scale-up

• Format: PDF

Produktbeschreibung

Master the design and operation of perfusion cell cultures with this authoritative reference. Discover the current state-of-the-art in the design and operation of continuous bioreactors, with emphasis on mammalian cell cultures for producing therapeutic proteins. Topics include the current market for recombinant therapeutic proteins, current industry challenges and the potential contribution of continuous manufacturing. Provides coverage of every step of process development and reactor operation, including small scale screening to lab-scale and scale-up to manufacturing scale. Illustrated through real-life case studies, this is a perfect resource for groups active in the cell culture field, as well as graduate students in areas such as chemical engineering, biotechnology, chemistry and biology, and to those in the pharmaceutical industry, particularly biopharma, biotechnology and food or agro industry.

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Produktdetails

• Verlag: Cambridge University Press (Virtual Publishing)
• Erscheinungstermin: 29. Juli 2020
• ISBN-13: 9781108848077
• Artikelnr.: 70912509

Autorenporträt

Moritz Wolf is a management consultant at McKinsey & Company and a former post-doctoral fellow at ETH Zurich in the department of Chemistry and Applied Biosciences. He has obtained the degree of Doctor of Science from ETH Zurich.

Inhaltsangabe

1. Perfusion mammalian cell culture for recombinant protein manufacturing
2. Perfusion bioreactors
3. Scale-down models and sensors for process development
4. Design and optimization of mammalian cell perfusion cultures
5. Clinical and commercial-scale reactors
6. Mechanistic and statistical modeling of bioprocesses.