Brian E. Cairns

Peripheral Receptor Targets for Analgesia (eBook, PDF)

Novel Approaches to Pain Management

• Format: PDF

Produktbeschreibung

A unique reference on peripheral pain receptor mechanisms While considerable advances have been made on pharmacotherapies for many chronic disease states, options available to treat chronic pain have remained relatively unchanged for decades. However, utilizing the receptors involved in peripheral pain transduction mechanisms offers a significant opportunity to create novel therapies for pain. A comprehensive review of peripheral pain mechanisms, Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management provides a unique resource that brings together a body of knowledge that was previously widely dispersed. As such, it gives readers a framework for further basic and clinical studies on potential receptor targets, as well as the development of improved topical analgesics. Coverage includes: * The latest discoveries by leading researchers relating to the function of various ion channels and receptors in the peripheral nervous system * Novel delivery techniques * An appendix listing currently available topical analgesic medications * A Foreword by Professor Lars Arendt-Nielsen of the Center for Sensory-Motor Interaction (SMI) at Aalborg University An unmatched resource for improving drug therapies and making pain management more efficient, Peripheral Receptor Targets for Analgesia supplies pharmaceutical scientists, pharmacologists, neuroscientists, and graduate and upper-level undergraduate students with a comprehensive, up-to-date reference.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 528
• Erscheinungstermin: 3. September 2009
• Englisch
• ISBN-13: 9780470522219
• Artikelnr.: 37293970

Autorenporträt

Brian Cairns is Canada Research Chair in Neuropharmacology and an Associate Professor in the Faculty of Pharmaceutical Sciences at the University of British Columbia. The author of book chapters (including in Wiley's Handbook of Pharmaceutical Biotechnology) and more than fifty journal articles, Dr. Cairns also teaches undergraduate and graduate students about pain research and treatment, and contributes to the activities of several well-known pain research societies.

Inhaltsangabe

FOREWORD by Lars Arendt-Nielsen.
PREFACE.
CONTRIBUTORS.
PART I PERIPHERAL MECHANISM IN CLINICAL PAIN CONDITIONS.
1. Role of Peripheral Mechanisms in Craniofacial Pain Conditions (Barry J.
Sessle).
2. Role of Peripheral Mechanisms in Spinal Pain Conditions (Brian E. Cairns
and Pradit Prateepavanich).
PART II SPECIFIC RECEPTOR TARGETS FOR PERIPHERAL ANALGESICS.
3. Voltage-Gated Sodium Channels in Peripheral Nociceptive Neurons as
Targets For the Treatment of Pain (Theodore R. Cummins).
4. Potassium Channels (Daisuke Nishizawa1, Toru Kobayashi, and Kazutaka
Ikeda).
5. Voltage-Gated Calcium Channels as Targets for the Treatment of Chronic
Pain (Joe McGivern).
6. Adenosine Receptors (Jana Sawynok).
7. Acid-Sensing Ion Channels and Pain (Roxanne Y. Walder, Christopher J.
Benson and Kathleen A. Sluka).
8. Vanilloid (TRPV1) and Other Transient Receptor Potential Channels (
Marcello Trevisani and Arpad Szallasi).
9. Glutamate Receptors (Brian E. Cairns).
10. Serotonin Receptors (Malin Ernberg).
11. Adrenergic Receptors (Antti Pertovaara).
12. Cholinergic Receptors and Botulinum Toxin (Parisa Gazerani).
13. Cannabinoids and Pain Control in the Periphery (Jason J. McDougall).
14. Opioid Receptors (Claudia Herrera Tambeli, Luana Fischer and Carlos
Amilcar Parada).
15. Calcitonin Gene-Related Peptide and Substance P (Ranjinidevi
Ambalavanar and Dean Dessem).
16. Role of Somatostatin and Somatostatin Receptors in Pain (Ujendra Kumar
).
17. Cytokines (Tumor Necrosis Factor, Interleukins) and Prostaglandins (
Per Alstergren).
18. Neurotrophic Factors and Pain (Peter Svensson).
PART III DELIVERY SYSTEMS.
19. Topical and Systemic Drug Delivery Systems Targeted Drug Therapy (Urs
Hafeli and Amit Kale).
20. Gene Therapy for Pain (Marina Mata and David J. Fink).
21. Topical Analgesics (Akhlaq Waheed Hakim and Brian E. Cairns).
Index.