Pharmacokinetics in Drug Discovery and Development (eBook, ePUB)

Redaktion: Schoenwald, Ronald D.

• Format: ePub

Produktbeschreibung

From basic principles to industrial and regulatory applications to clinical and research applications, this book provides a comprehensive review of all the subspecialties in the field. After an introduction of basic principles, the book is divided into sections that cover industrial and regulatory applications, clinical applications, and research applications. The following sections cover such topics as PK/PD approaches, clinical pharmacokinetic monitoring, population pharmacokinetics, linear systems approaches, and more. Fourteen authors, each an expert in his/her area of expertise, provide an extensive background into the subspeciality with emphasis on the section's theme.

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Produktdetails

• Verlag: Taylor & Francis
• Erscheinungstermin: 6. März 2002
• Englisch
• ISBN-13: 9781040064757
• Artikelnr.: 72281064

Autorenporträt

Ronald D. Schoenwald

Inhaltsangabe

BASIC PRINCIPLES: Basic Principles. INDUSTRIAL AND REGULATORY APPLICATIONS:
PK/PD Approach. Pharmacokinetics and Metabolism in Drug Discovery and
Preclinical Development. Phase I, II, and III FDA Submissions.
Bioavailability and Bioequivalence. CLINICAL APPLICATIONS: General
Approaches to Clinical Pharmacokinetic Monitoring. Aminoglycosides and
Other Antibiotics. Cardiovascular Agents. Psychotropic Agents.
Theophylline. Anticonvulsant Agents. RESEARCH APPLICATIONS: Classical
Modeling. Non-compartmental Modeling. Physiologically-Based Pharmacokinetic
Models. Population Pharmacokinetics. The Linear Systems Approach.