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Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with an overview of the current status of research into phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/ metabolic, pain, and allergy/respiratory diseases. Separate chapters describe the impact of structural biology on the development of selective inhibitors. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.
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