Phosphoinositides in Subcellular Targeting and Enzyme Activation (eBook, PDF)

Redaktion: Stenmark, Harald

• Format: PDF

Produktbeschreibung

The reversible recruitment of intracellular protein complexes to membranes is essential for immune cell functions, including chemotaxis, phagocytosis and signalling. Such recruitment is often controlled by phosphorylated derivatives of phosphatidylinositol, known as phosphoinositides. These lipids also serve to activate enzyme systems that carry out complex reactions such as chromatin remodelling and pre-mRNA procesing. This issue of Current Topics in Microbiology and Immunology presents an overview of how phosphoinositides function in protein recruitment and enzyme activation and presents physiologically important examples of protein-phosphoinositide interactions.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 209
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783642188053
• Artikelnr.: 53091382

Inhaltsangabe

List of Contents.- Phosphoinositide Involvement in Phagocytosis and Phagosome Maturation.- Regulation of Endocytosis by Phosphatidylinositol 4,5-Biphosphate and ENTH Proteins.- Membrane Targeting by Pleckstrin Homology Domains.- Protein Targeting to Endosomes and Phagosomes via FYVE and PX Domains.- Regulation of the Actin Cytoskeleton by PI(4,5)P2 and PI(3,4,5)P3.- Roles of PI3K in Neutrophil Function.- Nuclear Phosphoinositides and Their Functions.

Rezensionen

From the reviews:

"The book consists of seven chapters that focus on the various functions of PtdIns. ... summarises recent advances in the burgeoning field of inositol lipids and provides a snapshot of where the field stands in 2003. The field is moving rapidly but this volume will be a useful addition for many researchers who have only recently discovered that their favourite protein is regulated by PtdIns." (Shamshad Cockcroft, nature cell biology, Vol. 6 (6), June, 2004)