Literature Review from the year 2014 in the subject Biology - Botany, , course: post doctoral, language: English, abstract: Biotechnologists in recent years have come up with a new concept. This new concept is about edible vaccine. Edible vaccines are composed of antigenic proteins and do not contain pathogenic genes (because obviously they use attenuated strains). Thus, they have no way of establishing infection and safety is assured. Edible vaccines hold great promise as a cost-effective, easy-to-administer, easy-to-store, fail-safe and socioculturally readily acceptable vaccine delivery system, especially for the poor developing countries. It involves introduction of selected desired genes into plants and then inducing these altered plants to manufacture the encoded proteins. Resistance to genetically modified foods may affect the future of edible vaccines. This Review article include many aspects related to plant derived vaccine like Molecular farming, Process of development of plant derived vaccines,Mechanism of action.recent research regarding development of edible vaccines against cholera, malaria, Hepatites B, rabies etc.The review article gives a overall picture of Plant derived vaccine