Plasma Membrane Shaping (eBook, ePUB)

Redaktion: Suetsugu, Shiro

• Format: ePub

Produktbeschreibung

Plasma Membrane Shaping summarizes current knowledge on how cells shape their membrane. Organized in four sections, the book opens with a broad overview of the plasma membrane, its composition, usual shapes and substructures, Actin/WASP/arp2/3 structures, BAR domains, and Ankyrin repeat domains, dynamin, and phospholipid signaling. Other sections cover the shaping of the plasma membrane for transport processes, discussions on exosomes, microvesicles, and endosomes, clathrin-coated pits, caveolae, and other endocytic pits, membrane deformation for cell movement, and some of the most current dry and wet lab research techniques to investigate cellular membrane shaping.

This is an ideal resource for new researchers coming into this area as well as for graduate students. The methods section will be of interest to both microscopists and computer scientists dedicated to the visualization, data collection, and analysis of plasma membrane shaping experiments.

• Covers membrane shaping for both cytosis and cell movement
• Includes dry and wet lab research methods of plasma membrane shaping
• Describes the molecular machinery involved with protein and lipid balance in the plasma membrane
• Presents the coordination of cellular structures involved in cell deformation and motion

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 468
• Erscheinungstermin: 8. September 2022
• Englisch
• ISBN-13: 9780323899192
• Artikelnr.: 65685675

Inhaltsangabe

1. Introduction and overview of the book
Part 1: Building blocks and the shape builders 2. Membrane lipid
compositions and the difference between subcellular structures 3.
Wiskott4. BAR domains 5. Ankyrin repeat domains with an amphipathic helix for
membrane deformation 6. Ankyrin repeat domains 7. Dynamin: molecular
scissors for membrane fission 8. Phospholipid signaling, lipase 9.
Phospholipid signaling: phosphoinositide kinases and phosphatases 10.
Plasma membrane shaping by protein phase separation 11. Synthetic mimics of
membrane-active proteins and peptides
Part 2: The functions of the plasma membrane substance and derived vesicles
12. The extracellular vesicles 13. Regulation of membrane traffic through
recycling endosomes by membrane phospholipid phosphatidylserine 14.
Membrane shaping for clathrin-coated pits and endocytosis 15. Caveolae
biogenesis and lipid sorting at the plasma membrane 16. Non-vesicular lipid
transport at membrane contact sites between the endoplasmic reticulum and
the plasma membrane 17. Lamellipodia and filopodia 18. Membrane structures,
dynamics, and shaping in invadopodia and podosomes
Part 3: Force around the plasma membrane and imaging 19. Membrane tension
and mechanobiology of cell migration 20. Brownian ratchet force sensor at
the contacting point between F-actin barbed end and lamellipodium tip
plasma membrane 21. Biophysics of cellular membrane shaping on fiber
networks 22. Reconstitution of membrane symmetry breaking
Part 4: The microscopy and image analysis for understanding the shaping of
the membrane 23. Imaging three-dimensional dynamics of plasma membrane
structures using ultrathin plane illumination microscopy 24. Deep learning
for cell shape analysis
Part 5: The essentiality of the membrane shaping by theory and
reconstitution 25. Physical principles of cellular membrane shapes 26.
Modeling cellular shape changes in the presence of curved membrane proteins
and active cytoskeletal forces 27. Molecular dynamics