Platelet Membrane Glycoproteins (eBook, PDF)

Redaktion: George, James N.

• Format: PDF

Produktbeschreibung

It was just about ten years ago that platelet membrane glycoproteins were first charac terized and their abnormalities in congenital bleeding disorders first recognized. Dur ing this decade there has been a remarkable growth in our understanding of the structure and membrane organization of the platelet surface glycoproteins, their in teractions with external ligands during the process of hemostasis, and their defects causing hemorrhagic disease. These studies have advanced the knowledge of platelet involvement in hemostasis from a cellular to a molecular level, and they have provided a model for contact interactions among other cell types. This seemed a proper time to ask those who contributed major observations and insights during these past years to review their progress and to assess the state of our present knowledge. We have planned this volume to begin with the biochemistry of platelet membrane glycoproteins themselves and proceed through their involvement in platelet function to the final considerations of the platelet's role in maintaining the integrity of the vascular system. Our aim was an integrated presentation on the blood platelet from the perspective of its highly specialized and reactive cell surface. James N. George Alan T. Nurden David R. Phillips vii Contents I. INTRODUCTION 1. Plasma Membrane Receptors and Platelet Response Ernst F. Wscher 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Platelet Receptor Functions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 . . . . . . . . . . 2. 1. Receptors Involved in Platelet Adhesion and in Cell-Cell Contact. . . 5 2. 2. Receptors Involved in Platelet Activation. . . . . . . . . . . . . . . . . . . 6 . . . . 3. Conclusion. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 II.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 420
• Erscheinungstermin: 13. März 2013
• Englisch
• ISBN-13: 9781468448801
• Artikelnr.: 43987941

Inhaltsangabe

I. Introduction.- 1. Plasma Membrane Receptors and Platelet Response.- II. Plasma Membrane and Membrane Glycoprotein Structure and Function.- 2. Structural and Molecular Properties of Platelet Membrane Systems.- 3. Glycoproteins of the Platelet Plasma Membrane.- 4. Organization of Glycoproteins within the Platelet Plasma Membrane.- 5. Structure and Function of Platelet Membrane Glycoproteins as Studied by Crossed Immunoelectrophoresis.- 6. Platelet Membrane Electrical Potential: Its Regulation and Relationship to Platelet Activation.- III. Interaction of Platelet Membrane Glycoproteins With The Extracellular Environment.- 7. Receptors for Platelet Agonists.- 8. Secreted Alpha Granule Proteins: The Race for Receptors.- 9. The Platelet-Fibrinogen Interaction.- 10. Platelet-von Willebrand Factor Interactions.- 11. Molecular Mechanisms of Platelet Adhesion and Platelet Aggregation.- 12. Lectin-Carbohydrate Binding as a Model for Platelet Contact Interactions.- IV. Interactions of Platelet Membrane Glycoproteins with the Intracellular Cytoskeleton.- 13. The Organization of Platelet Contractile Proteins.- 14. The Mechanism of Clot Retraction.- V. Platelet Membrane Glycoprotein Immunology and Abnormalities.- 15. Immunology of the Platelet Surface.- 16. Glycoprotein Defects Responsible for Abnormal Platelet Function in Inherited Platelet Disorders.- VI. Conclusion.- 17. The Role of Membrane Glycoproteins in Platelet Formation, Circulation, and Senescence: Review and Hypotheses.