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The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation…mehr
The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.
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DR. ÁNGEL GARCÍA is currently a Ramón y Cajal Research Fellow at the Pharmacology Department, Universidade de Santiago de Compostela, Spain. His main research focus is in the area of platelet proteomics, with special emphasis in cardiovascular research and platelet signaling studies. He has written over twenty publications in peer-reviewed journals and has been an invited lecturer at the Platelets 2010 International Symposium (Jerusalem, Israel), and the XXII Congress of the International Society on Thrombosis and Haemostasis, held in Boston, United States, in 2009, where he chaired a session on novel approaches to understanding platelet biology. Dr. García was a postdoctoral research associate of the Proteomics Group at the Oxford Glycobiology Institute, University of Oxford (UK), from 2001 to 2005. DR. YOTIS SENIS is currently a British Heart Foundation Research Fellow at the University of Birmingham, United Kingdom. He is a senior member of the Birmingham Platelet Group. Dr. Senis' research interests include the identification of novel platelet surface glycoproteins and determining their biological and molecular functions. He is also interested in the functional roles of protein tyrosine phosphatases in platelets and thrombosis. Dr. Senis has been an invited lecturer at the Platelet 2010 International Symposium (Jerusalem, Israel) and the Gordon Research Conference on the Cell Biology of Megakaryocytes and Platelets (Galveston, Texas). He has written over twenty publications on platelet signaling and thrombosis.
Inhaltsangabe
Foreword xiii Preface xv Acronyms xvii Part I General Overview: Platelets, Sample Preparation, and Mass Spectrometry-Based Proteomics 1 Platelets and Their Role in Thrombotic and Cardiovascular Disease: The Impact of Proteomic Analysis 3 Ronald G. Stanley, Katherine L. Tucker, Natasha E. Barrett, and Jonathan M. Gibbins 2 Mass-Spectrometry-Based Proteomics: General Overview and Posttranslational Modification Analysis in the Context of Platelet Research 27 Julia Maria Burkhart and Albert Sickmann 3 Sample Preparation Variables in Platelet Proteomics for Biomarker Research 67 Maria Zellner and Rudolf Oehler Part II Analysis of The Platelet Proteome: Global Approaches and Subproteomes 4 Two-Dimensional Gel Electrophoresis: Basic Principles and Application to Platelet Signaling Studies 89 Ángel García 5 The Platelet Membrane Proteome 111 Yotis A. Senis 6 Proteomics of Platelet Granules, Organelles, and Releasate 139 James P. McRedmond 7 The Platelet Microparticle Proteome 159 David M. Smalley 8 N-Terminal Combined Fractional Diagonal Chromatographic (COFRADIC) Analysis of the Human Platelet Proteome 185 Francis Impens, Kenny Helsens, Niklaas Colaert, Lennart Martens, Joël Vandekerckhove, and Kris Gevaert Part III Integrated "Omics" and Application to Disease 9 Serial Analysis of Gene Expression (SAGE) For Studying the Platelet and Megakaryocyte Transcriptome 209 Michael G. Tomlinson 10 The Application of Microarray Analysis and Its Integration with Proteomics for Study of Platelet-Associated Disorders 231 Dmitri V. Gnatenko and Wadie F. Bahou 11 Platelet Functional Genomics 253 Isabelle I. Salles, Marie N. O'Connor, Daphne C. Thijssen-Timmer, Katleen Broos, and Hans Deckmyn 12 Systems Biology to Study Platelet-Related Bleeding Disorders 285 Jan-Willem N. Akkerman and Bernard De Bono 13 Platelet Proteomics in Transfusion Medicine 321 Thomas Thiele, Leif Steil, Uwe Völker, and Andreas Greinacher 14 Cardiovascular Proteomics 341 Fernando Vivanco, Fernando de la Cuesta, Maria G. Barderas, Irene Zubiri, and Gloria Álvarez-Llamas Index 381
Foreword xiii Preface xv Acronyms xvii Part I General Overview: Platelets, Sample Preparation, and Mass Spectrometry-Based Proteomics 1 Platelets and Their Role in Thrombotic and Cardiovascular Disease: The Impact of Proteomic Analysis 3 Ronald G. Stanley, Katherine L. Tucker, Natasha E. Barrett, and Jonathan M. Gibbins 2 Mass-Spectrometry-Based Proteomics: General Overview and Posttranslational Modification Analysis in the Context of Platelet Research 27 Julia Maria Burkhart and Albert Sickmann 3 Sample Preparation Variables in Platelet Proteomics for Biomarker Research 67 Maria Zellner and Rudolf Oehler Part II Analysis of The Platelet Proteome: Global Approaches and Subproteomes 4 Two-Dimensional Gel Electrophoresis: Basic Principles and Application to Platelet Signaling Studies 89 Ángel García 5 The Platelet Membrane Proteome 111 Yotis A. Senis 6 Proteomics of Platelet Granules, Organelles, and Releasate 139 James P. McRedmond 7 The Platelet Microparticle Proteome 159 David M. Smalley 8 N-Terminal Combined Fractional Diagonal Chromatographic (COFRADIC) Analysis of the Human Platelet Proteome 185 Francis Impens, Kenny Helsens, Niklaas Colaert, Lennart Martens, Joël Vandekerckhove, and Kris Gevaert Part III Integrated "Omics" and Application to Disease 9 Serial Analysis of Gene Expression (SAGE) For Studying the Platelet and Megakaryocyte Transcriptome 209 Michael G. Tomlinson 10 The Application of Microarray Analysis and Its Integration with Proteomics for Study of Platelet-Associated Disorders 231 Dmitri V. Gnatenko and Wadie F. Bahou 11 Platelet Functional Genomics 253 Isabelle I. Salles, Marie N. O'Connor, Daphne C. Thijssen-Timmer, Katleen Broos, and Hans Deckmyn 12 Systems Biology to Study Platelet-Related Bleeding Disorders 285 Jan-Willem N. Akkerman and Bernard De Bono 13 Platelet Proteomics in Transfusion Medicine 321 Thomas Thiele, Leif Steil, Uwe Völker, and Andreas Greinacher 14 Cardiovascular Proteomics 341 Fernando Vivanco, Fernando de la Cuesta, Maria G. Barderas, Irene Zubiri, and Gloria Álvarez-Llamas Index 381
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