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Using clear and practical examples, this volume presents a comprehensive examination of polymorphic behavior in pharmaceutical development. The book is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This second edition focuses on the pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins. Topics in this edition include computational methodologies, high-throughput screening methods, pharmaceutical cocrystals, and thermally-induced and solution-mediated phase transformations. The book also examines amorphous solids, the amorphous state, and crystallography preparation and characterization.
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