Joachim Chrubasik, Sigrun Chrubasik, Laurence Mather

Postoperative Epidural Opioids (eBook, PDF)

• Format: PDF

Produktbeschreibung

Epidural opioids are widely used in the management of post- operative pain. On the basis of an extensive review of the literature the authors here present their own interpretation of current knowledge of how the distribution and effectiveness of epidurally administered opiods are fundamentally determined. They conclude that all opioids that are currently being used to treat postoperative epidural pain carry the potential risk of severe side effects if the dose regimens are not tailored to the patient`s individual analgesic need. This book will serve to stimulate new ideas among pain specialistst.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 119
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783642783203
• Artikelnr.: 53141489

Inhaltsangabe

Epidural and Intrathecal Space.- Anatomy.- Puncture of the Meninges.- Distribution of Solutions.- Determinants of Opioid Activity.- Physicochemical Properties.- Distribution and Elimination.- Opioid Receptors.- Opioid Pharmacokinetics After Epidural Administration.- Transfer Across the Meninges.- Uptake into the CSF.- Distribution within the CSF.- Elimination from CSF.- Uptake into Spinal Cord and Brain.- Uptake into Epidural Fat.- Vascular Uptake into the Systemic Circulation.- Elimination from Blood.- Summary.- Clinical Implications.- Onset Time of Analgesia.- Duration of Action.- Side-Effects.- Quality of Analgesia.- Summary.- Relative Analgesic Potencies.- Definition.- Quantitation from Postoperative Dose Requirements..- Interpretation.- Summary.- Risk-Benefit Evaluation.- Morphine.- Meperidine.- Methadone.- Alfentanil.- Fentanyl.- Sufentanil.- Buprenorphine.- Tramadol.- Summary.- References.