The book contains chapters encompassing common designs along with advantages and limitations of such designs, analytic aspects in planning trials and estimating sample size, and how to use patient partners to help design and operationalize pragmatic randomized trials. Pragmatic trials conducted using primary data collection and trials embedded in electronic health records - including electronic medical records and administrative insurance claims - are addressed.
This comprehensive resource is valuable not only for pharmacoepidemiologists, biostatisticians and clinical researchers, but also across the biomedical field for those who are interested in applying pragmatic randomized clinical trials in their research.
- Addresses typical designs and challenges of pragmatic randomized clinical trials (pRCTs)
- Encompasses analytic aspects of such trials
- Discusses real cases on operational challenges in launching and conducting pRCTs in electronic health records
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