Privileged Scaffolds in Drug Discovery (eBook, ePUB)

Redaktion: Yu, Bin; Fu, Caiyun; Li, Ning

• Format: ePub

Produktbeschreibung

Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development.

The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years.

Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable.

• Provides wide coverage of privileged scaffolds in new drug discovery
• Includes complex and diverse natural product scaffolds
• Covers applications to peptides and peptide-based drugs

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 850
• Erscheinungstermin: 19. Juli 2023
• Englisch
• ISBN-13: 9780443186127
• Artikelnr.: 68451716

Inhaltsangabe

1. Thiazole, a privileged scaffold in new drug discovery 2. Chalcone:
Diverse biological activities and structure-activity relationships 3.
Privileged chalcone scaffolds in drug discovery 4. The N-sulfonyl
carboxamide moiety as a privileged structure in approved drugs 5. Scaffolds
in cytotoxic drugs and novel antitumor molecules interacting with nucleic
acids 6. Triazoles: a privileged scaffold in drug design and novel drug
discovery 7. Oxazolidinone scaffolds in drug discovery and development 8.
Indole and indoline scaffolds in drug discovery 9. Cyanopyridine as a
privileged scaffold in drug discovery 10. Indazole as privileged scaffold
in drug discovery 11. (Benz)imidazoles: privileged scaffolds in medicinal
chemistry 12. Tranylcypromine (TCP): a privileged scaffold for designing
histone lysine demethylase 1 inhibitors 13. Applications of piperazine
scaffold in drug design 14. Thiols as a privileged scaffold against
metallo-ß-lactamases 15. Tetrahydro-ß-carboline scaffold in drug discovery
16. Benzoxaborole: a privileged scaffold for drug discovery 17. Privileged
scaffolds in anti-diabetic drug discovery 18. Authentic HIV-1 integrase
inhibitors for the treatment of HIV-1/AIDS 19. 2-Aminopyrimidine: a
privileged scaffold in kinase drug discovery 20. Alzheimer's disease
therapeutics: current strategies and future directions 21. Sulfonyl
fluorides as warheads in drug discovery 22. ¿,ß-Bifunctionalized carbonyl
compounds as privileged motifs in drug discovery and their synthetic
protocols 23. Diarylpyrimidines and related analogs as antiviral agents 24.
Organic synthetic methodology-based new scaffold in drug discovery 25.
Natural resource of anti-human immunodeficiency virus leading compounds:
tigliane diterpenoids 26. Biological phenethyl glycosides from plants 27.
Triterpenoids and saponins in drug discovery 28. Casbene-derived
diterpenoids 29. Quassinoids: phytochemistry and antitumor prospect 30.
Structural diversity, biosynthesis, and biological functions of
meroterpenoids from microbial metabolites 31. Glucocorticoid compounds in
drug discovery by targeting glucocorticoid receptor protein 32. Peptide and
peptide-based drugs 33. Stapled peptides for new drug discovery 34. Current
status and trends in research and development of polypeptide drugs 35.
Unique opportunities of metal scaffolds in drug design 36. N-Heterocyclic
carbene as privileged scaffold in medicinal inorganic chemistry 37.
Selenium-containing heterocycles 38. Computational methods for scaffold
hopping