Process Chemistry in the Pharmaceutical Industry (eBook, PDF)

Redaktion: Gadamasetti, Kumar

• Format: PDF

Produktbeschreibung

Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchersa "offering a solid grounding in synthetic "and" physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs.

Featuring over 1000 references, tables, and illustrations, "Process Chemistry in the Pharmaceutical Industry" is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 500
• Erscheinungstermin: 6. Mai 1999
• Englisch
• ISBN-13: 9781482276091
• Artikelnr.: 57589625

Autorenporträt

Kumar Gadamasetti

Inhaltsangabe

Overview
Process Chemistry in the Pharmaceutical Industry: An Overview, Kumar G.
Gadamasetti
Strategy
Process Research and Development Strategy for Accelerated Projects,
Christopher M. Cimarusti
Case Studies
A Practical Synthesis of Ifetroban Sodium, Richard H. Mueller
Synthesis of 5-Lipoxygenase Inhibitors, Ivan Lantos and Richard Matsuoka
Chemistry of Vitamin D: A Challenging Field for Process Research, Masami
Okabe
A Highly Optimized and Concise Large Scale Synthesis of a Purine
Bronchodilator, Hans-Jürgen Federsel and Edib Jakupovic
Ontazolast: The Evolution of a Process, Vittorio Farina, Karl Grozinger,
Hermann Müller-Bötticher and Gregory P. Roth
Dilevalol Hydrochloride: Development of a Commercial Process, Derek Walker
Design and Development of Practical Syntheses of LY228729, a Potent 5HT1a
Receptor Agonist, Michael J. Martinelli and David L. Varie
Process Research and Development of CGS 19755, an NMDA Antagonist, Peter
Giannousis, John Carlson and Marius Leimer
Route Evaluation for the Production of (R)-Levoprotiline, H. U. Blaser, R.
Gamboni, B. Pugin, G. Rihs, G. Sedelmeier, E. Schaub, E. Schmidt, B.
Schmitz, F. Spindler and Hj. Wetter
The Process Research and Development of DuPont Merck's Cyclic Urea Diols, A
New Class of HIV Protease Inhibitors, Pat N. Confalone and Robert E.
Waltermire
Practical Enantio- and Diastereo-selective Processes for Azetidinones, T.
K. Thiruvengadam, Anantha R. Sudhakar, and Guangzhong Wu
Synthesis of the Common Lactone Moiety of HMG-CoA Reductase Inhibitors,
Ian M. McFarlane, Christopher G. Newton and Philippe Pitchen
Enzymatic Intervention and Phase Transfer Catalysis
Chemistry, Biocatalysis and Engineering: An Interdisciplinary Approach to
the Manufacture of the Benzodiazepine Drug Candidate LY 300164, Benjamin A.
Anderson, Marvin M. Hansen, Jeffrey T. Vicenzi and Milton J. Zmijewski
Benefits and Challenges of Applying Phase-Transfer Catalysis Technology in
the Pharmaceutical Industry, Marc E. Halpern
Asymmetric Synthesis and Enantioselectivity
Enantioselective Synthesis: The Optimum Process, John J. Partridge and
Brian L. Bray
Practical Catalysts for Asymmetric Synthesis: Ligands from Natural Sugars
for Rh-Catalyzed Asymmetric Synthesis of D- and L- Amino Acids, Timothy A.
Ayers and T. V. Rajan Babu
Chiral (Salen)Mn(III) Complexes in Asymmetric Epoxidations: Practical
Synthesis of cis-Aminoindanol and Its Application to Enantiopure Drug
Synthesis, Chris H. Senanayake and Eric N. Jacobsen
Drug Substance Final Form and Process Safety
Chemical Development of the Drug Substance Solid Form, Michael D. Thompson
and Jean-René Authelin
The Basic Principles of Thermal Process Safety: Towards a Better
Communication Between Safety Experts and Process Chemists, Wilfried
Hoffmann
Design of Experiments and Automation
Using Factorial Experiments in the Development of Process Chemistry,
Daniel R. Pilipauskas
Laboratory Automation in Chemical Development, Martin R. Owen and Sheila H.
Dewitt