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This title, the 52nd in symposium series, presents a comprehensive review of apoptosis and features contributions from many internationally recognised authors.
This title, the 52nd in symposium series, presents a comprehensive review of apoptosis and features contributions from many internationally recognised authors.
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Autorenporträt
School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK. School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK. School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK.
Inhaltsangabe
Contributors Abbreviations Preface 1 Apoptotic cell death: from worms to wombats ... but what about the weeds? 1 /M.O. Hengartnerand J.A. Bryant Caenorhabditis elegans: the worm that turned ... into a model multicellular eukaryote The molecular mechanisms of programmed cell death in Caenorhabditis elegans Comparison with mammalian apoptosis Plants, from Arabidopsis to Zinnia General conclusions 2 Caspases at the cutting edge of cell death /H.R. Stennicke Introduction Caspases and their properties Structure of the caspases Activation and regulation of the caspases Evolution of the caspases 3 Modulation of death receptor signalling /P. Schneider and J.Tschopp Introduction Death receptors and apoptosis Activation of death receptors by death ligands Decoy receptors Inhibition of death receptor by FLIP Conclusion 4 The role of the Bcl 2 family in the modulation of apoptosis /C. Pepper and P. Bentley Introduction Bcl 2 family: life or death promoters Function of the Bcl 2 family proteins Cellular control of Bcl 2 family proteins Over expression of Bcl 2 family proteins and chemoresistance Drug resistance in B CLL Strategies for inhibiting Bcl 2 function in B CLL Conclusions 5 The role of granzymes and serpins in regulating cell growth and death /P. Coughlin, E. Morris and L. Hampson Introduction Induction of apoptosis by cytotoxic T cells and natural killer cells How does granzyme B gain access to the interior of target cells? Molecular targets of granzyme B Regulation of granzyme B activity The intracellular regulation of granzyme B by PI 9 The role of intracellular serpins in cell growth and death Conclusions 6 Mitochondria and cell death: a pore way to die? /A.P. Halestrap, J.P. Gillespie, A. O'Toole and E. Doran Introduction The mitochondrial permeability transition Mitochondria and apoptosis 7 Regulation of apoptosis by cell metabolism
Contributors Abbreviations Preface 1 Apoptotic cell death: from worms to wombats ... but what about the weeds? 1 /M.O. Hengartnerand J.A. Bryant Caenorhabditis elegans: the worm that turned ... into a model multicellular eukaryote The molecular mechanisms of programmed cell death in Caenorhabditis elegans Comparison with mammalian apoptosis Plants, from Arabidopsis to Zinnia General conclusions 2 Caspases at the cutting edge of cell death /H.R. Stennicke Introduction Caspases and their properties Structure of the caspases Activation and regulation of the caspases Evolution of the caspases 3 Modulation of death receptor signalling /P. Schneider and J.Tschopp Introduction Death receptors and apoptosis Activation of death receptors by death ligands Decoy receptors Inhibition of death receptor by FLIP Conclusion 4 The role of the Bcl 2 family in the modulation of apoptosis /C. Pepper and P. Bentley Introduction Bcl 2 family: life or death promoters Function of the Bcl 2 family proteins Cellular control of Bcl 2 family proteins Over expression of Bcl 2 family proteins and chemoresistance Drug resistance in B CLL Strategies for inhibiting Bcl 2 function in B CLL Conclusions 5 The role of granzymes and serpins in regulating cell growth and death /P. Coughlin, E. Morris and L. Hampson Introduction Induction of apoptosis by cytotoxic T cells and natural killer cells How does granzyme B gain access to the interior of target cells? Molecular targets of granzyme B Regulation of granzyme B activity The intracellular regulation of granzyme B by PI 9 The role of intracellular serpins in cell growth and death Conclusions 6 Mitochondria and cell death: a pore way to die? /A.P. Halestrap, J.P. Gillespie, A. O'Toole and E. Doran Introduction The mitochondrial permeability transition Mitochondria and apoptosis 7 Regulation of apoptosis by cell metabolism
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