Programmed Cell Death in Animals and Plants (eBook, PDF)

Redaktion: Bryant, John; Hughes, S. G.; Garland, Jeff

• Format: PDF

Produktbeschreibung

This title, the 52nd in symposium series, presents a comprehensive review of apoptosis and features contributions from many internationally recognised authors.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 328
• Erscheinungstermin: 24. Dezember 2021
• Englisch
• ISBN-13: 9781000102345
• Artikelnr.: 63134391

Autorenporträt

School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK. School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK. School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK.

Inhaltsangabe

Contributors
Abbreviations
Preface
1 Apoptotic cell death: from worms to wombats ... but what about the weeds? 1 /M.O. Hengartnerand J.A. Bryant
Caenorhabditis elegans: the worm that turned ... into a model multicellular eukaryote
The molecular mechanisms of programmed cell death in Caenorhabditis elegans
Comparison with mammalian apoptosis
Plants, from Arabidopsis to Zinnia
General conclusions
2 Caspases
at the cutting edge of cell death /H.R. Stennicke
Introduction
Caspases and their properties
Structure of the caspases
Activation and regulation of the caspases
Evolution of the caspases
3 Modulation of death receptor signalling /P. Schneider and J.Tschopp
Introduction
Death receptors and apoptosis
Activation of death receptors by death ligands
Decoy receptors
Inhibition of death receptor by FLIP
Conclusion
4 The role of the Bcl
2 family in the modulation of apoptosis /C. Pepper and P. Bentley
Introduction
Bcl
2 family: life or death promoters
Function of the Bcl
2 family proteins
Cellular control of Bcl
2 family proteins
Over
expression of Bcl
2 family proteins and chemoresistance
Drug resistance in B
CLL
Strategies for inhibiting Bcl
2 function in B
CLL
Conclusions
5 The role of granzymes and serpins in regulating cell growth and death /P. Coughlin, E. Morris and L. Hampson
Introduction
Induction of apoptosis by cytotoxic T cells and natural killer cells
How does granzyme B gain access to the interior of target cells?
Molecular targets of granzyme B
Regulation of granzyme B activity
The intracellular regulation of granzyme B by PI
9
The role of intracellular serpins in cell growth and death
Conclusions
6 Mitochondria and cell death: a pore way to die? /A.P. Halestrap, J.P. Gillespie, A. O'Toole and E. Doran
Introduction
The mitochondrial permeability transition
Mitochondria and apoptosis
7 Regulation of apoptosis by cell metabolism