Programmed Cell Death in Cancer Progression and Therapy (eBook, PDF)

Redaktion: Khosravi-Far, Roya; White, Eileen

• Format: PDF

Produktbeschreibung

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.

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Produktdetails

• Verlag: Springer Netherlands
• Seitenzahl: 356
• Erscheinungstermin: 29. Dezember 2007
• Englisch
• ISBN-13: 9781402065545
• Artikelnr.: 37340988

Inhaltsangabe

Cell Death: History and Future.- Caspase Mechanisms.- The Mitochondrial Death Pathway.- Apoptotic Pathways in Tumor Progression and Therapy.- Therapeutic Targeting of Death Pathways in Cancer: Mechanisms for Activating Cell Death in Cancer Cells.- Overcoming Resistance to Apoptosis in Cancer Therapy.- Trail Receptors: Targets for Cancer Therapy.- Rational Design of Therapeutics Targeting the BCL-2 Family: Are Some Cancer Cells Primed for Death but Waiting for a Final Push?.- Autophagy and Tumor Suppression: Recent Advances in Understanding the Link between Autophagic Cell Death Pathways and Tumor Development.- Regulation of Programmed Cell Death by the P53 Pathway.- Regulation of Programmed Cell Death by NF-?B and its Role in Tumorigenesis and Therapy.- Targeting Proteasomes as Therapy in Multiple Myeloma.- Histone Deacetylase Inhibitors: Mechanisms and Clinical Significance in Cancer: HDAC Inhibitor-Induced Apoptosis.- RNA Interference and Cancer: Endogenous Pathways and Therapeutic Approaches.- Cancer Stem Cells and Impaired Apoptosis.

Rezensionen

From the reviews:

"Programmed cell death (PCD) is an intriguing term that was introduced by Richard Lockshin nearly 45 years ago. ... this book is about PCD with intense focus on apoptosis and the exploitation of PCD for treating cancer. ... All chapters are well edited and thoroughly referenced. The nicety of the book is the use of numerous color figures. In my opinion, both scientists and clinicians, experienced or beginning, will profit from a thoughtful reading of Programmed Cell Death in Cancer Progression and Therapy." (A. A. Philchenkov, Biochemistry (Moscow), Vol. 74 (4), 2009)