Progress in the Chemistry of Organic Natural Products 115 (eBook, PDF)

Redaktion: Kinghorn, A. Douglas; Dirsch, Verena M.; Liu, Ji-Kai; Asakawa, Yoshinori; Gibbons, Simon; Falk, Heinz

• Format: PDF

Produktbeschreibung

This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca²⁺ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.

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Produktdetails

• Verlag: Springer International Publishing
• Seitenzahl: 203
• Erscheinungstermin: 2. April 2021
• Englisch
• ISBN-13: 9783030648534
• Artikelnr.: 61391179

Inhaltsangabe

Total Synthesis of Decanolides (Nonanolides) with a Special Focus on Olefin Metathesis.- From Plant to Patient: Thapsigargin.- Antileishmanial Activity of Lignans and Neolignans.- Cryptolepine as a Lead to new Antiprotozoal Agents.- Biologically Active Constituents from Plants of the Genus Xanthium.