Proceedings of the XIth International Washington Spring Symposium at the George Washington University, held in Washington, D.C., May 13-17, 1991
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Inhaltsangabe
I - Molecular Biology and Enzymology of Prostaglandins and Leukotrienes.- 1. Translational Control of Prostaglandin Synthase by Growth Factors and Glucocorticoids.- 2. Two Types of Arachidonate 12-Lipoxygenase Demonstrated by Enzymological and Molecular Immunological and Molecular Biological Studies.- 3. A Model for the Transcriptional Regulation of a Mouse PGH Synthase Gene.- 4. Catalytic Properties and Reaction Mechanism of 5-Lipoxygenase.- 5. Cloning, Expression and Site-Directed Mutagenesis of the cDNA for Human Placental NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase.- 6. Regulation of Cyclooxygenase Gene Expression in Vascular Endothelial Cells.- 7. Structure-Function Studies and Physiological Roles of Eicosanoids Metabolized by Cytochrome P450 ?-Hydrolases.- 8. Multiple Cyclooxygenases: Cloning of a Mitogen Inducible Form.- 9. Amino Acids Essential to Catalysis by Prostaglandin Endoperoxide Synthase.- 10. Allene Oxide Biosynthesis and Metabolism.- 11. Lipoxygenase, Cyclooxygenase and Leukotriene A4 Hydrolase: Quantitative Polymerase Chain Reaction and Expression Studies.- II - Regulatory Mechanisms in Eicosanoid Release and Metabolism.- 12. Annexins and Signal Transduction.- 13. Structural and Functional Properties of Mammalian Group III Cytosolic Phospholipases A2.- 14. Regulation of Plasma Membrane Phospholipase A2 Activity by Phosphorylation/Dephosphorylation: Is Glucocorticoid Action Mediated by Induction of Protein Phosphatase?.- 15. Eicosanoid/Signal Transduction Interactions: Evidence of Two Induced Pathways of Phosphoinositide Biosynthesis by LTB4 in Cultured Human Epidermal Cells.- 16. Prostaglandyl-Inositol Cyclic-Phosphate, A New Second Messenger.- 17. Incorporation of Hydroxyeicosatetraenoic Acids into Phospholipid Signalling Pathways.- 18.The Purification of Two Intracellular Phospholipase A2's and the Effects of Phopholipase A2 Activating Protein and Mellitin on Their Activities.- 19. Differential Activation of Phospholipase A2 Activity and Prostacyclin Production in Rat Vascular Smooth Muscle Cells and Cardiomyocytes.- III - Cardiovascular Pulmonary Interactions of Prostaglandins, Prostacyclins and Leukotrienes.- 20. Thromboxane A2/Prostaglandin H2 Receptors: A Growing Family of Receptor Subtypes.- 21. The Regulation of Prostacyclin Secretion in Endothelial Cells.- 22. Metabolism of Arachidonic Acid by Purified Lung Epithelial Cells.- 23. Recovery of Human Tracheal Cell Epithelial Cell Cyclooxygenase Following Inactivation.- 24. Aortic Microsomal Prostacyclin Synthesis During Diet Induced Hypercholesterolemia.- 25. Activation of Protein Kinase C Regulates LTB4 Receptor on Guinea Pig Eosinophils.- IV - Recent Advance in Paf Metabolism and Function.- 26. Novel Neutrophil Agonists: Oxidatively-Fragmented Phosphatidylcholines.- 27. Specific Binding of Tritium-Labeled Platelet-Activating Factor to Human Mononuclear Leukocyte Membranes: A Third Putative Receptor of Platelet-Activating Factor.- 28. Tyrosine Kinase Phosphorylation in Human Neutrophil Activation by PAF and Other Agonists.- 29. Platelet-Activating Factor (PAF) Receptor in Brain and Signal Transduction in Neurons.- V - Immune Reactions, Cancer and Inflammatory Processes.- 30. Influence of PGE2 and LTB4 on CD8+ Thymocytes.- 31. Modulation of Cytokine Gene Expression by LTB4 and PAF: Transcriptional and Post-Transcriptional Regulation.- 32. Hepoxilin A3 Induces Vascular Permeability in the Skin.- 33. Lipoxygenase Metabolism in the Regulation of Hematopoiesis.- 34. Lipid Bodies: Structurally Distinct, Non-Membranous Intracellular Sites ofEicosanoid Formation.- 35. Tumor Prostaglandins and Estrogen Receptors: Prediction of Survival in Patients with Early Breast Cancer.- VI - Clinical and Pharmacological Applications of Eicosanoids.- 36. Lipid Mediators in Transplantation Reperfusion Injury, Acute Rejection and Accelerated Transplant Atherosclerosis.- 37. Pharmacological Profile, Pharmacokinetics and Biotransformation of the 5-Lipoxygenase Inhibitor FLM 5011.- 38. Prostaglandin H Synthase: Perturbation of the Tyrosyl Radical as a Probe of Anti-Cyclooxygenase Agents.- 39. Selective Incorporation of HETEs into Epidermal Phospholipids.- 40. Lipoxin Generation in Human Whole Blood: Monitoring by Electron-Capture NICI/GC/MS.- 41. Therapeutic Aspects of Leukotriene Antagonists and Inhibitors.- 42. Tolerance to Cardiac Grafts Following Intra-Graft Infusion of 16,16 Dimethyl PGE2.
I - Molecular Biology and Enzymology of Prostaglandins and Leukotrienes.- 1. Translational Control of Prostaglandin Synthase by Growth Factors and Glucocorticoids.- 2. Two Types of Arachidonate 12-Lipoxygenase Demonstrated by Enzymological and Molecular Immunological and Molecular Biological Studies.- 3. A Model for the Transcriptional Regulation of a Mouse PGH Synthase Gene.- 4. Catalytic Properties and Reaction Mechanism of 5-Lipoxygenase.- 5. Cloning, Expression and Site-Directed Mutagenesis of the cDNA for Human Placental NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase.- 6. Regulation of Cyclooxygenase Gene Expression in Vascular Endothelial Cells.- 7. Structure-Function Studies and Physiological Roles of Eicosanoids Metabolized by Cytochrome P450 ?-Hydrolases.- 8. Multiple Cyclooxygenases: Cloning of a Mitogen Inducible Form.- 9. Amino Acids Essential to Catalysis by Prostaglandin Endoperoxide Synthase.- 10. Allene Oxide Biosynthesis and Metabolism.- 11. Lipoxygenase, Cyclooxygenase and Leukotriene A4 Hydrolase: Quantitative Polymerase Chain Reaction and Expression Studies.- II - Regulatory Mechanisms in Eicosanoid Release and Metabolism.- 12. Annexins and Signal Transduction.- 13. Structural and Functional Properties of Mammalian Group III Cytosolic Phospholipases A2.- 14. Regulation of Plasma Membrane Phospholipase A2 Activity by Phosphorylation/Dephosphorylation: Is Glucocorticoid Action Mediated by Induction of Protein Phosphatase?.- 15. Eicosanoid/Signal Transduction Interactions: Evidence of Two Induced Pathways of Phosphoinositide Biosynthesis by LTB4 in Cultured Human Epidermal Cells.- 16. Prostaglandyl-Inositol Cyclic-Phosphate, A New Second Messenger.- 17. Incorporation of Hydroxyeicosatetraenoic Acids into Phospholipid Signalling Pathways.- 18.The Purification of Two Intracellular Phospholipase A2's and the Effects of Phopholipase A2 Activating Protein and Mellitin on Their Activities.- 19. Differential Activation of Phospholipase A2 Activity and Prostacyclin Production in Rat Vascular Smooth Muscle Cells and Cardiomyocytes.- III - Cardiovascular Pulmonary Interactions of Prostaglandins, Prostacyclins and Leukotrienes.- 20. Thromboxane A2/Prostaglandin H2 Receptors: A Growing Family of Receptor Subtypes.- 21. The Regulation of Prostacyclin Secretion in Endothelial Cells.- 22. Metabolism of Arachidonic Acid by Purified Lung Epithelial Cells.- 23. Recovery of Human Tracheal Cell Epithelial Cell Cyclooxygenase Following Inactivation.- 24. Aortic Microsomal Prostacyclin Synthesis During Diet Induced Hypercholesterolemia.- 25. Activation of Protein Kinase C Regulates LTB4 Receptor on Guinea Pig Eosinophils.- IV - Recent Advance in Paf Metabolism and Function.- 26. Novel Neutrophil Agonists: Oxidatively-Fragmented Phosphatidylcholines.- 27. Specific Binding of Tritium-Labeled Platelet-Activating Factor to Human Mononuclear Leukocyte Membranes: A Third Putative Receptor of Platelet-Activating Factor.- 28. Tyrosine Kinase Phosphorylation in Human Neutrophil Activation by PAF and Other Agonists.- 29. Platelet-Activating Factor (PAF) Receptor in Brain and Signal Transduction in Neurons.- V - Immune Reactions, Cancer and Inflammatory Processes.- 30. Influence of PGE2 and LTB4 on CD8+ Thymocytes.- 31. Modulation of Cytokine Gene Expression by LTB4 and PAF: Transcriptional and Post-Transcriptional Regulation.- 32. Hepoxilin A3 Induces Vascular Permeability in the Skin.- 33. Lipoxygenase Metabolism in the Regulation of Hematopoiesis.- 34. Lipid Bodies: Structurally Distinct, Non-Membranous Intracellular Sites ofEicosanoid Formation.- 35. Tumor Prostaglandins and Estrogen Receptors: Prediction of Survival in Patients with Early Breast Cancer.- VI - Clinical and Pharmacological Applications of Eicosanoids.- 36. Lipid Mediators in Transplantation Reperfusion Injury, Acute Rejection and Accelerated Transplant Atherosclerosis.- 37. Pharmacological Profile, Pharmacokinetics and Biotransformation of the 5-Lipoxygenase Inhibitor FLM 5011.- 38. Prostaglandin H Synthase: Perturbation of the Tyrosyl Radical as a Probe of Anti-Cyclooxygenase Agents.- 39. Selective Incorporation of HETEs into Epidermal Phospholipids.- 40. Lipoxin Generation in Human Whole Blood: Monitoring by Electron-Capture NICI/GC/MS.- 41. Therapeutic Aspects of Leukotriene Antagonists and Inhibitors.- 42. Tolerance to Cardiac Grafts Following Intra-Graft Infusion of 16,16 Dimethyl PGE2.
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