Protein Folding, Misfolding and Aggregation (eBook, PDF)

Classical Themes and Novel Approaches
Redaktion: Muñoz, Victor

• Format: PDF

Produktbeschreibung

Protein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods have evolved to permit resolving fast processes of folding reactions and visualizing single molecules during folding. The findings from these novel experiments and detailed computer simulations have confirmed the main predictions of analytical theory of protein folding. In summary, protein folding research has finally acquired the status of a truly quantitative science, paving the way for more exciting developments in the near future. This unique book covers all the modern approaches and the many advances experienced in the field during the last 10 years. There is also much emphasis on computational methods and studies of protein aggregation which have really flourished in the last decade. It includes chapters in the areas that have witnessed major developments and are written by top experts including:computer simulations of folding, fast folding, single molecule spectroscopy, protein design, aggregation studies (both computational and experimental). Readers will obtain a unique perspective of the problems faced in the biophysical study of protein conformational behaviour in aqueous solution and how these problems are being solved with a multidisciplinary approach that combines theory, experiment and computer simulations. Protein Folding, Misfolding and Aggregation Classical Themes and Novel Approaches is essential reading for graduate students actively involved in protein folding research, other scientists interested in the recent progress of the field and instructors revamping the protein folding section of their biochemistry and biophysics courses.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 288
• Erscheinungstermin: 24. Juni 2008
• Englisch
• ISBN-13: 9781847558282
• Artikelnr.: 44765856

Autorenporträt

Victor Mu±oz is Associate Professor in Chemistry and Biochemistry at the University of Maryland, USA and Research Professor in Biophysics at the Spanish Research Council (CSIC), Madrid, Spain. He has worked in the area of protein folding and aggregation for the last 16 years and for the last 7 years he has been involved in promoting a change from the classical biochemical to a physical paradigm in experimental protein folding.

Inhaltsangabe

Preface: Classical Themes and Novel Approaches in Protein Folding and Aggregation
Chapter 1: The Helix as the Simplest Protein Folding Model
Helix-Coil Theory, Stability and Design
Chapter 2: Kinetics and Mechanisms of -Helix Formation
Chapter 3: Protein Folding Theory
The Folding Energy Landscape: A Primer
Chapter 4: Hydrogen Exchange Experiments
Detection and Characterization of Folding Intermediates
Chapter 5: Statistical Differential Scanning Calorimetry
Probing Protein Folding-Unfolding Ensembles
Chapter 6: Fast Protein Folding
Chapter 7: Single Molecule Spectroscopy in Protein Folding
From Ensembles to Single Molecules
Chapter 8: Computer Simulations of Protein Folding
Chapter 9: Protein Design
Tailoring Sequence, Structure and Folding Properties
Chapter 10: Protein Misfolding and -Amyloid Formation
Chapter 11: Computational Studies of Protein Aggregation
Molecular Dynamics Simulations and Bioinformatic Analysis of Scenarios for Protein Aggregation