Quantitative Systems Pharmacology (eBook, ePUB)

Models and Model-Based Systems with Applications
Redaktion: Manca, Davide

• Format: ePub

Produktbeschreibung

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more.

As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource.

• Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology
• Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy
• Discusses how drugs are driven to specific targets using nanoparticles
• Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance
• Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 418
• Erscheinungstermin: 18. Juli 2018
• Englisch
• ISBN-13: 9780444639677
• Artikelnr.: 50902958