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This thesis reports on the development of the first quantum enhanced microscope and on its applications in biological microscopy. The first quantum particle-tracking microscope, described in detail here, represents a pioneering advance in quantum microscopy, which is shown to be a powerful and relevant technique for future applications in science and medicine. The microscope is used to perform the first quantum-enhanced biological measurements -- a central and long-standing goal in the field of quantum measurement. Sub diffraction-limited quantum imaging is achieved, also for the first…mehr
This thesis reports on the development of the first quantum enhanced microscope and on its applications in biological microscopy. The first quantum particle-tracking microscope, described in detail here, represents a pioneering advance in quantum microscopy, which is shown to be a powerful and relevant technique for future applications in science and medicine.
The microscope is used to perform the first quantum-enhanced biological measurements -- a central and long-standing goal in the field of quantum measurement. Sub diffraction-limited quantum imaging is achieved, also for the first time, with a scanning probe imaging configuration allowing 10-nanometer resolution.
Introduction.- Practical Quantum Measurements.- Introductory Theory of Optical Tweezers.- The Total Information Carried by the Light.- The Quantum Noise Limit for a Specific Measurement.- Characterizing Quadrant Detection.- Interferometer Enhanced Particle Tracking.- Homodyne Based Particle Tracking.- Lock-In Particle Tracking.- Selective Measurement by Optimized Dark-Field Illumination Angle.- Technical Constraints on Sensitivity.- Surpassing the Quantum Limit.- Biological Measurement Beyond the Quantum Limit.- Sub diffraction-Limited Quantum Imaging of a Living Cell.- Further Extensions.- Summary and Conclusion.
Introduction.- Practical Quantum Measurements.- Introductory Theory of Optical Tweezers.- The Total Information Carried by the Light.- The Quantum Noise Limit for a Specific Measurement.- Characterizing Quadrant Detection.- Interferometer Enhanced Particle Tracking.- Homodyne Based Particle Tracking.- Lock-In Particle Tracking.- Selective Measurement by Optimized Dark-Field Illumination Angle.- Technical Constraints on Sensitivity.- Surpassing the Quantum Limit.- Biological Measurement Beyond the Quantum Limit.- Sub diffraction-Limited Quantum Imaging of a Living Cell.- Further Extensions.- Summary and Conclusion.
Introduction.- Practical Quantum Measurements.- Introductory Theory of Optical Tweezers.- The Total Information Carried by the Light.- The Quantum Noise Limit for a Specific Measurement.- Characterizing Quadrant Detection.- Interferometer Enhanced Particle Tracking.- Homodyne Based Particle Tracking.- Lock-In Particle Tracking.- Selective Measurement by Optimized Dark-Field Illumination Angle.- Technical Constraints on Sensitivity.- Surpassing the Quantum Limit.- Biological Measurement Beyond the Quantum Limit.- Sub diffraction-Limited Quantum Imaging of a Living Cell.- Further Extensions.- Summary and Conclusion.
Introduction.- Practical Quantum Measurements.- Introductory Theory of Optical Tweezers.- The Total Information Carried by the Light.- The Quantum Noise Limit for a Specific Measurement.- Characterizing Quadrant Detection.- Interferometer Enhanced Particle Tracking.- Homodyne Based Particle Tracking.- Lock-In Particle Tracking.- Selective Measurement by Optimized Dark-Field Illumination Angle.- Technical Constraints on Sensitivity.- Surpassing the Quantum Limit.- Biological Measurement Beyond the Quantum Limit.- Sub diffraction-Limited Quantum Imaging of a Living Cell.- Further Extensions.- Summary and Conclusion.
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