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Radiobiology Self-Assessment Guide --a companion to the Radiation Oncology Self-Assessment Guide and Physics in Radiation Oncology Self-Assessment Guide --is a comprehensive review for practitioners of radiation oncology looking to enhance their knowledge of radiobiology. It covers in depth the principles of radiobiology as applied to radiation oncology along with their clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly "flash card" question and answer format with over 700 questions. The questions are supported by detailed answers and…mehr
Radiobiology Self-Assessment Guide--a companion to the Radiation Oncology Self-Assessment Guide and Physics in Radiation Oncology Self-Assessment Guide--is a comprehensive review for practitioners of radiation oncology looking to enhance their knowledge of radiobiology. It covers in depth the principles of radiobiology as applied to radiation oncology along with their clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly "flash card" question and answer format with over 700 questions. The questions are supported by detailed answers and rationales along with reference citations for source information.
The guide is comprised of 29 chapters and cover topics commonly found on the radiation and cancer biology portion of the radiation oncology board examination. Aspects of basic radiobiology covered include fundamentals such as cell cycle, cell survival curves and interactions of radiation with matter, and acute and long-term sequelae of radiation. Modern concepts such as immunotherapy, radiogenomics, and normal and cancer stem cells are also included. Focused and authoritative, this must-have review provides the expertise of faculty from the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute and Lerner Research Institute.
Key Features:
Provides a comprehensive study guide for the Radiation and Cancer Biology portion to the Radiation Oncology Board Exam
Includes more than 700 questions with detailed answers and rationales on flip pages for easy, flash card-like review
Includes essential review of cancer biology concepts such as immunotherapy, stem cells, gene therapy, chemotherapy and targeted agents
Content provided by a vast array of contributors, including attending radiation oncology physicians, physicists, and radiation oncology residents
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Autorenporträt
Jennifer Yu, MD, PhD, Associate Staff Physician, Departments of Radiation Oncology and Stem Cell Biology and Regenerative Medicine, Taussig Cancer Institute and Lerner Research Institute, Cleveland Clinic, Cleveland OH
Inhaltsangabe
CONTENTS Contributors Preface 1. Interaction of Radiation With Matter John F. Greskovich, Jr., Mihir Naik, and Marc Apple 2. Cell Survival Curves and Cell Death Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan 3. DNA, Chromosome and Chromatid Damage, Repair, and Measurement Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan 4. Radiosensitivity and the Dose-Rate Effect Brian D. Yard and Mohamed E. Abazeed 5. Radiation Damage Repair and Models for Normal Tissues Aditya Juloori, Choamei Xiang, Michael A. Weller, and Jennifer S. Yu 6. Hypoxia, Oxygen, Reoxygenation, and Angiogenesis Xingjiang Yu, Jennifer S. Yu, and Eli Bar 7. Linear Energy Transfer and Relative Biological Effectiveness Yvonne Pham and Chirag Shah 8. Assays for Cell, Tissue, and Solid Tumors C. Marc Leyrer, Ehsan H. Balagamwala, and Camille Berriochoa 9. Molecular Techniques, Assay Systems, and Signaling in Radiobiology Kailin Yang and Jennifer S. Yu 10. Biology of Cancer Kailin Yang and Jennifer S. Yu 11. Model Tumor Systems and Predictive Assays C. Marc Leyrer, Camille Berriochoa, and Ehsan H. Balagamwala 12. Cell Kinetics Matthew C. Ward and Richard Blake Ross 13. Factors Influencing Tumor Control and Complications Daesung Lee 14. Impact of Time, Dose, and Fractionation in Radiation Oncology Daesung Lee 15. Effects of Total Body Irradiation Sudha Amarnath 16. Radiation Sensitizers, Radioprotectors, and Bioreductive Drugs Aditya Juloori and Michael A. Weller 17. Radiation Carcinogenesis Bindu V. Manyam and Michael A. Weller 18. Effects of Radiation on Hereditary Damage, Mutations, and Chromosome Aberrations Camille Berriochoa, C. Marc Leyrer, and Anthony Mastroianni 19. Effects of Radiation on the Embryo and Fetus Yvonne Pham and Steven Oh 20. Doses and Risks in Nonradiation Oncology Subspecialties Frank Dong, Kevin Wunderle, and Salim Balik 21. Radiation Protection Taoran Cui and Peng Qi 22. Alternative Radiation Therapy Modalities Susan Kost and Andrew Godley 23. Brachytherapy and Stereotactic Radiosurgery Sudha Amarnath 24. Gene Therapy HyeonJoo Cheon 25. Chemotherapy and Targeted Agents Nikhil Joshi and Neil Woody 26. Hyperthermia Sharvari Dharmaiah, Vinay Rao, and Jennifer S. Yu 27. Stem Cells Haidong Huang and Jennifer S. Yu 28. Immunotherapy Nikhil Joshi and Neil Woody 29. Radiogenomics Mohamed E. Abazeed Index
CONTENTS Contributors Preface 1. Interaction of Radiation With Matter John F. Greskovich, Jr., Mihir Naik, and Marc Apple 2. Cell Survival Curves and Cell Death Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan 3. DNA, Chromosome and Chromatid Damage, Repair, and Measurement Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan 4. Radiosensitivity and the Dose-Rate Effect Brian D. Yard and Mohamed E. Abazeed 5. Radiation Damage Repair and Models for Normal Tissues Aditya Juloori, Choamei Xiang, Michael A. Weller, and Jennifer S. Yu 6. Hypoxia, Oxygen, Reoxygenation, and Angiogenesis Xingjiang Yu, Jennifer S. Yu, and Eli Bar 7. Linear Energy Transfer and Relative Biological Effectiveness Yvonne Pham and Chirag Shah 8. Assays for Cell, Tissue, and Solid Tumors C. Marc Leyrer, Ehsan H. Balagamwala, and Camille Berriochoa 9. Molecular Techniques, Assay Systems, and Signaling in Radiobiology Kailin Yang and Jennifer S. Yu 10. Biology of Cancer Kailin Yang and Jennifer S. Yu 11. Model Tumor Systems and Predictive Assays C. Marc Leyrer, Camille Berriochoa, and Ehsan H. Balagamwala 12. Cell Kinetics Matthew C. Ward and Richard Blake Ross 13. Factors Influencing Tumor Control and Complications Daesung Lee 14. Impact of Time, Dose, and Fractionation in Radiation Oncology Daesung Lee 15. Effects of Total Body Irradiation Sudha Amarnath 16. Radiation Sensitizers, Radioprotectors, and Bioreductive Drugs Aditya Juloori and Michael A. Weller 17. Radiation Carcinogenesis Bindu V. Manyam and Michael A. Weller 18. Effects of Radiation on Hereditary Damage, Mutations, and Chromosome Aberrations Camille Berriochoa, C. Marc Leyrer, and Anthony Mastroianni 19. Effects of Radiation on the Embryo and Fetus Yvonne Pham and Steven Oh 20. Doses and Risks in Nonradiation Oncology Subspecialties Frank Dong, Kevin Wunderle, and Salim Balik 21. Radiation Protection Taoran Cui and Peng Qi 22. Alternative Radiation Therapy Modalities Susan Kost and Andrew Godley 23. Brachytherapy and Stereotactic Radiosurgery Sudha Amarnath 24. Gene Therapy HyeonJoo Cheon 25. Chemotherapy and Targeted Agents Nikhil Joshi and Neil Woody 26. Hyperthermia Sharvari Dharmaiah, Vinay Rao, and Jennifer S. Yu 27. Stem Cells Haidong Huang and Jennifer S. Yu 28. Immunotherapy Nikhil Joshi and Neil Woody 29. Radiogenomics Mohamed E. Abazeed Index
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