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Plant polyphenols are specialized metabolites that constitute one of the most common and widespread groups of natural products. They are essential plant components for adaptation to the environment and possess a large and diverse range of biological functions that provide many benefits to both plants and humans. Polyphenols, from their structurally simplest forms to their oligo/polymeric versions (i.e. tannins and lignins), are phytoestrogens, plant pigments, antioxidants, and structural components of the plant cell wall. The interactions between tannins and proteins are involved in plant…mehr
Plant polyphenols are specialized metabolites that constitute one of the most common and widespread groups of natural products. They are essential plant components for adaptation to the environment and possess a large and diverse range of biological functions that provide many benefits to both plants and humans. Polyphenols, from their structurally simplest forms to their oligo/polymeric versions (i.e. tannins and lignins), are phytoestrogens, plant pigments, antioxidants, and structural components of the plant cell wall. The interactions between tannins and proteins are involved in plant defense against predation, cause astringency in foods and beverages, and affect the nutritional and health properties of human and animal food plants. This eighth volume of the highly regarded Recent Advances in Polyphenol Research series is edited by Juha-Pekka Salminen, Kristiina Wähälä, Victor de Freitas, and Stéphane Quideau, and brings together chapters written by some of the leading experts working in the polyphenol sciences today. Topics covered include: * Structure, reactivity and synthesis * Bioactivity and bioavailability * Metabolomics, targeted analysis and big data * Quality control & standardization * Biogenesis and functions in plants and ecosystems * Biomaterials & applied sciences Distilling the most recent and illuminating data available, this new volume is an invaluable resource for chemists, biochemists, plant scientists, pharmacognosists and pharmacologists, biologists, ecologists, food scientists and nutritionists.
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Juha-Pekka Salminen, current Communication Manager of Groupe Polyphénols (board member since 2018), is Full Professor of Natural Compound Chemistry at the University of Turku, Finland. His research group specializes in analytical chemistry, chemical ecology and bioactivity studies of large polyphenols, with a focus on ellagitannins and proanthocyanidins and their distribution and significance in the plant kingdom. Kristiina Wähälä, current Vice-President of the Groupe Polyphénols (2012-2014, 2018-2020) is Professor of Organic Chemistry at the University of Helsinki, Finland. Her research is focused on synthesis, analysis, and isotopical labelling of plant polyphenols and their metabolites in humans in connection with drug discovery and binding studies to target enzymes. The focus on her chemical synthesis is on environmentally benign methods, green chemistry and biomass utilization. Victor de Freitas, former President of the Groupe Polyphénols (2016-2021), is Full Professor at the Faculty of Sciences of the University of Porto, Portugal. His research on polyphenols include: structural characterization, chemical transformations in plants and foods during harvest and storage, influence on the sensory properties of foods (color, astringency and bitterness), and other biological properties. Stéphane Quideau, former President of the Groupe Polyphénols (2008-2012), is Full Professor of Organic and Bioorganic Chemistry at the University of Bordeaux, France, and Senior Member of the "Institut Universitaire de France." His laboratory is involved in research on plant polyphenol chemistry and chemical biology, with particular interests in ellagitannin chemical reactivity and synthesis, and in polyphenol-protein interactions.
Inhaltsangabe
Contributors
Preface
Acknowledgements
1 Lignins and Lignification: New Developments and Emerging Concepts John Ralph, Hoon Kim, Fachuang Lu, Rebecca A. Smith, Steven D. Karlen, Nuoendagula, Koichi Yoshioka, Alexis Eugene, Sarah Liu, Canan Sener, Daisuke Ando, Mingjie Chen, Yanding Li, Leta L. Landucci, Sally A. Ralph, Vitaliy I. Timokhin, Wu Lan, Jorge Rencoret, José C. del Río
1.1 Introduction
1.2 The monolignol pathway and interacting pathways -- New lignins
1.3 Lignin conjugates, 'clip-offs' -- new discoveries, and enhancing levels
1.4 Features of lignification, and the possibility of new polymerization pathways
1.5 The value of model studies and synthesis -- a reminder
1.6 New or improved analytics
1.7 Conclusions and Opportunities
2 Synthesis of epigallocatechin gallate, nobiletin and their derivatives for chemical-biology studies Tomohiro Asakawa, Makoto Inai and Toshiyuki Kan
2.1 Synthetic investigations of catechin derivatives
2.2 Synthesis and application of fluorescent catechin probes
2.3 Generation of catechin antibody
2.4 PET imaging of biodistribution of catechin
2.5 Practical synthesis of nobiletin
2.6 Derivatization of desmethyl nobiletins
2.7 PET imaging of biodistribution of nobiletin
2.8 Synthesis and application of fluorescent nobiletin probe
2.9 Conclusions
3 Procyanidins in the Onset and Progression of Colorectal Cancer: Recent Advances and Open Questions Wei Zhu, Gerardo G. Mackenzie and Patricia I. Oteiza
3.1 Introduction
3.2 Procyanidins:chemistry and metabolism
3.3 Procyanidins and CRC: epidemiological evidence
3.4 Procyanidins and CRC: rodent studies
3.5 Procyanidins and CRC: mechanisms of actions
3.6 Conclusions and open questions
3.7 Acknowledgements
4 The Potential of Low Molecular Weight (Poly)phenol Metabolites for Attenuating Neuroinflammation and Treatment of Neurodegenerative Diseases Daniela Marques, Rafael Carecho, Diogo Carregosa and Cláudia Nunes dos Santos
4.1 Introduction - Neurodegenerative disorders, dietary (poly)phenols and neuroinflammation
4.2 (Poly)phenols metabolism and distribution
4.3 (Poly)phenol metabolites and their brain permeability
4.4 LMW (poly)phenols metabolites as effectors for attenuating neuroinflammation
4.5 Concluding remarks
5 Deciphering Complex Natural Mixtures through Metabolome Mining of Mass Spectrometry Data: the Plant Specialized Metabolome as a Case Study Justin J.J. van der Hooft, Madeleine Ernst, Daniel Papenberg, Kyo Bin Kang, Iris F. Kappers, Marnix H. Medema, Pieter C. Dorrestein, and Simon Rogers
5.1 Introduction
5.2 Materials and methods
5.3 Results and discussion
5.4 Current limitations
5.5 Conclusions
5.6 Outlook
5.7 Acknowledgements
6 Application of MS-based Metabolomics to Investigate Biomarkers of Apple Consumption Resulting from Microbiota and Host Metabolism Interactions Fulvio Mattivi and Maria M. Ulaszewska
6.1 Introduction
6.2 Materials and methods
6.3 Results and discussion
6.4 Conclusions
7 Non-extractable polyphenols should be systematically included in polyphenols analysis Enrique Báez-García, Sonia G. Sáyago-Ayerdi and Jara Pérez-Jiménez
7.1 Introduction: the concept of non-extractable polyphenols
7.2 Analysis of non-extractable polyphenols
7.3 Why should non-extractable polyphenols be systematically included in polyphenol analysis?
1 Lignins and Lignification: New Developments and Emerging Concepts John Ralph, Hoon Kim, Fachuang Lu, Rebecca A. Smith, Steven D. Karlen, Nuoendagula, Koichi Yoshioka, Alexis Eugene, Sarah Liu, Canan Sener, Daisuke Ando, Mingjie Chen, Yanding Li, Leta L. Landucci, Sally A. Ralph, Vitaliy I. Timokhin, Wu Lan, Jorge Rencoret, José C. del Río
1.1 Introduction
1.2 The monolignol pathway and interacting pathways -- New lignins
1.3 Lignin conjugates, 'clip-offs' -- new discoveries, and enhancing levels
1.4 Features of lignification, and the possibility of new polymerization pathways
1.5 The value of model studies and synthesis -- a reminder
1.6 New or improved analytics
1.7 Conclusions and Opportunities
2 Synthesis of epigallocatechin gallate, nobiletin and their derivatives for chemical-biology studies Tomohiro Asakawa, Makoto Inai and Toshiyuki Kan
2.1 Synthetic investigations of catechin derivatives
2.2 Synthesis and application of fluorescent catechin probes
2.3 Generation of catechin antibody
2.4 PET imaging of biodistribution of catechin
2.5 Practical synthesis of nobiletin
2.6 Derivatization of desmethyl nobiletins
2.7 PET imaging of biodistribution of nobiletin
2.8 Synthesis and application of fluorescent nobiletin probe
2.9 Conclusions
3 Procyanidins in the Onset and Progression of Colorectal Cancer: Recent Advances and Open Questions Wei Zhu, Gerardo G. Mackenzie and Patricia I. Oteiza
3.1 Introduction
3.2 Procyanidins:chemistry and metabolism
3.3 Procyanidins and CRC: epidemiological evidence
3.4 Procyanidins and CRC: rodent studies
3.5 Procyanidins and CRC: mechanisms of actions
3.6 Conclusions and open questions
3.7 Acknowledgements
4 The Potential of Low Molecular Weight (Poly)phenol Metabolites for Attenuating Neuroinflammation and Treatment of Neurodegenerative Diseases Daniela Marques, Rafael Carecho, Diogo Carregosa and Cláudia Nunes dos Santos
4.1 Introduction - Neurodegenerative disorders, dietary (poly)phenols and neuroinflammation
4.2 (Poly)phenols metabolism and distribution
4.3 (Poly)phenol metabolites and their brain permeability
4.4 LMW (poly)phenols metabolites as effectors for attenuating neuroinflammation
4.5 Concluding remarks
5 Deciphering Complex Natural Mixtures through Metabolome Mining of Mass Spectrometry Data: the Plant Specialized Metabolome as a Case Study Justin J.J. van der Hooft, Madeleine Ernst, Daniel Papenberg, Kyo Bin Kang, Iris F. Kappers, Marnix H. Medema, Pieter C. Dorrestein, and Simon Rogers
5.1 Introduction
5.2 Materials and methods
5.3 Results and discussion
5.4 Current limitations
5.5 Conclusions
5.6 Outlook
5.7 Acknowledgements
6 Application of MS-based Metabolomics to Investigate Biomarkers of Apple Consumption Resulting from Microbiota and Host Metabolism Interactions Fulvio Mattivi and Maria M. Ulaszewska
6.1 Introduction
6.2 Materials and methods
6.3 Results and discussion
6.4 Conclusions
7 Non-extractable polyphenols should be systematically included in polyphenols analysis Enrique Báez-García, Sonia G. Sáyago-Ayerdi and Jara Pérez-Jiménez
7.1 Introduction: the concept of non-extractable polyphenols
7.2 Analysis of non-extractable polyphenols
7.3 Why should non-extractable polyphenols be systematically included in polyphenol analysis?
7.4 Relevance of
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