Redox Chemistry and Biology of Thiols (eBook, ePUB)

Redaktion: Alvarez, Beatriz; Trujillo, Madia; Salinas, Gustavo; Comini, Marcelo

• Format: ePub

Produktbeschreibung

Redox Chemistry and Biology of Thiols offers an applied, comprehensive overview of redox chemistry and biology of thiol-dependent processes. Running from basic biology and chemistry of redox phenomena to research methods and highlighting recently identified roles of thiols across cellular and bodily systems, this book draws upon a range of disciplines to illuminate new research directions, new applications of thiol studies, and clinical translation. Sections cover thiol oxidizing species, thiol reactivity and modifications, thioredoxin, glutaredoxin, glutathione, peroxidases, thiol repair enzymes, thiol oxidative signaling, disulfide bond formation, thiol-based redox biosensors, cysteine and hydrogen sulfide metabolism, iron-sulfur cluster biogenesis, thiols in chloroplasts, blood thiols, sugar and polyamine thiols in pathogenic organisms, redox medicine (therapeutic applications of thiols and drug development), as well as methods and bioinformatics tools.

• Runs from basic thiol biology and chemistry to applications and clinical translation
• Provides methods and protocols that will power new research across biomedicine, cell biology, plant biology, drug development, and protein folding and modulation
• Includes chapter contributions from international leaders in the field

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 746
• Erscheinungstermin: 25. Mai 2022
• Englisch
• ISBN-13: 9780323915663
• Artikelnr.: 64096976

Inhaltsangabe

1. Basic concepts of thiol chemistry and biology 2. Chemical basis of
cysteine reactivity: Acidity and nucleophilicity 3. Computational
functional analysis of cysteine residues in proteins 4. Global approaches
for protein thiol redox state detection and quantification 5. Thiol
oxidation by biologically-relevant reactive species 6. Thiyl radicals:
formation, properties and detection 7. Detection of the oxidation products
of thiols: disulfides, sulfenic, sulfinic and sulfonic acids 8.
Biochemistry and detection of S-nitrosothiols 9. Thiol modification and
signaling by biological electrophiles 10. Thioredoxin and glutathione
reductases 11. Functional plasticity in the thioredoxin family: FeS-thio-
and glutaredoxins 12. Glutathione and glutathione-dependent enzymes 13.
Thiol and selenol-based peroxidases: Structure and catalytic properties 14.
Thiol peroxidase-based redox relays 15. Compartmentalized disulphide bond
formation pathways 16. Disulfide bond formation in Escherichia coli 17.
Thiol-based redox probes 18. Selenocysteine-containing proteins 19.
Overview of cysteine metabolism 20. Hydrogen sulfide and persulfides 21.
The role of thiols in iron-sulfur cluster biogenesis 22. Thiol-based redox
control in chloroplasts 23. Sugar-based cysteine thiols recruited for
oxidative stress defence and redox regulation 24. Polyamine-based thiols in
pathogens 25. Thiols in blood 26. A thiol chemistry perspective on redox
medicine 27. Therapeutic applications of low-molecular-weight thiols and
selenocompounds 28. Thiol targets in drug development to combat bacterial
infections