Subsequently, methodological issues are examined, including the use of the systemic and network approach in neuropsychological research, the concepts of single and double dissociation, single-case versus group studies, problems of brain-behavioral correlations using the lesion method and functional neuroimaging, the influence of task-relevant variables (confounders) related to the patient (e.g., age, education), to the lesion (size, etiology), and to the tests and testing conditions (ecological validity, examiner¿s experience). Finally, readers are given the fundamentals of statistics applied to biomedical and psychological research, with illustrative examples of how to calculate Z score, effect size, ¿2 test, t test, Pearson¿s correlation coefficient, and simple linear regression. Methodological problems in current cognitive research on early multiple sclerosis, medial temporal lobe epilepsy, mild cognitive impairment and dementia are examined in detail.
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