Restoration of Brain Function by Tissue Transplantation (eBook, PDF)

Redaktion: Lindvall, Olle

• Format: PDF

Produktbeschreibung

Cell transplantation to the brain and spinal cord is a well-established research tool for studies on cellular and molecular mechanisms, but can it be developed into a useful therapuetic approach in human neurological disorders? Clinical trials in patients with Parkinson's disease have provided encouraging evidence, however, no treatment based on transplantation is available yet. An overview of current research is given in this book. It summarizes the status of grafting in humans and discusses scientific problems that have to be solved before intracerebral transplantation can become a useful routine approach to treatment.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 74
• Erscheinungstermin: 7. März 2013
• Englisch
• ISBN-13: 9783642777189
• Artikelnr.: 53090671

Inhaltsangabe

References.- Transplantation in Parkinson's Disease.- Experimental Studies in Animal Models of Parkinson's Disease.- Clinical Studies in Patients with Parkinson's Disease.- Research Strategies for the Development of a Transplantation Therapy in Parkinson's Disease.- Conclusions.- References.- Transplantation in Huntington's Disease: Experimental Basis and Clinical Perspectives.- Experimental Model.- Implants of Fetal Striatal Primordia.- Intrinsic Organization of the Striatal Grafts.- Biochemical Markers of Striatal Graft Maturation and Function.- Amelioration of Lesion-Induced Behavioral Deficits.- Mechanisms of Action of the Intrastriatal Grafts.- Afferent Regulation of the Grafted Neurons.- Trophic Effects of Striatal Transplants.- Studies in Primates.- Clinical Perspectives.- References.- Neural Transplantation in Dementia.- Common Terminology in Research on Alzheimer's Disease.- Models of Cholinergic Deficiency.- Models of Trophic Factor Deficiency.- Critical Neuropathology of Alzheimer's Disease.- Graft Models of the Cellular Pathology of Alzheimer's Disease.- Clinical Prospects in Dementia.- References.- Transplantation in Experimental Epilepsy.- Noradrenergic Grafts in Experimental Epilepsy.- Other Grafts in Experimental Epilepsy.- Present Lines of Research and Clinical Perspectives.- Concluding Remarks.- References.- Genetically Modified Cells for Intracerebral Transplantation.- Genetically Modified Cells and the Neurotrophic Strategy.- Genetically Modified Cells for Neurotransmitter Replacement.- Discussion and Future Directions.- References.- Immunologic Aspects of Intracerebral CNS Tissue Transplantation.- General Aspects of Transplantation Immunology.- The Brain as a Transplantation Site.- Immunologic Experience of IntracerebralTransplantation in Patients with Parkinson's Disease.- Conclusions.- References.