Rethinking Cancer (eBook, ePUB)

A New Paradigm for the Postgenomics Era
Redaktion: Strauss, Bernhard; Bissell, Mina J.; Ernberg, Ingemar; Bertolaso, Marta

• Format: ePub

Produktbeschreibung

Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence.

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Produktdetails

• Verlag: MIT Press
• Seitenzahl: 432
• Erscheinungstermin: 27. April 2021
• Englisch
• ISBN-13: 9780262362085
• Artikelnr.: 59925250

Autorenporträt

edited by Bernhard Strauss, Marta Bertolaso, Ingemar Ernberg, and Mina J. Bissell

Inhaltsangabe

Series Foreword ix
Preface xi
1 Introduction and Overview 1
I REDEFINING THE PROBLEM: THE THEORY DIMENSION OF CANCER 11
2 The Search for Progress and a New Theory Framework in Cancer Research 13
3 Cancer as a System: Hard Lessons from Physics and a Way Forward 41
II THE SYSTEMS DIMENSION OF CANCER 61
4 The Logic of Cancer Treatment: Why It Is So Hard to Cure Cancer;
Treatment-Induced Progression, Hyper-Progression, and the Nietzsche Effect
63
5 The Cell Attractor Concept as a Tool to Advance Our Understanding of
Cancer 129
6 Adaptation of Molecular Interaction Networks in Cancer Cells 141
7 The Role of Genomic Dark Matter in Cancer: Using AI to Shine a Light on
It; Why Cancer Genes Are Not the Whole Story 163
III THE TIME DIMENSION OF CANCER 185
8 Darwinism, Not Mutationalism, for New Cancer Therapies 187
9 Cancer as a Reversion to an Ancestral Phenotype 205
10 Time and Timing in Oncology: What Therapy Scheduling Can Teach Us about
Cancer Biology 227
IV THE MICRO-/ENVIRONMENT DIMENSION OF CANCER 245
11 Tissue Tension Modulates Metabolism and Chromatin Organization to
Promote Malignancy 247
12 Cancer Metabolism and Therapeutic Perspectives: Exploiting Acidic,
Nutritional, and Oxidative Stresses 271
13 Corrupted Vascular Tumor Niches Confer Aggressiveness and
Chemoresistance to Neoplastic Cells 299
14 Metastasis as a Tug of War between Cell Autonomy and Microenvironmental
Control: Readdressing Unresolved Questions in Cancer Metastasis 323
15 Niche Reconstruction to Revert or Transcend the Cancer State 353
V WHAT NEXT? 391
Contributors 397
Index 399