Riboflavin (eBook, PDF)

Redaktion: Rivlin, Richard

• Format: PDF

Produktbeschreibung

This volume represents an interdisciplinary approach to an understanding of the chemistry, physiology, and medical significance of the vitamin riboflavin. Information has been reviewed on the physiological role of the vitamin, the metabolic effects of riboflavin deficiency in animals and man, and the regulation of riboflavin metabolism. In each chapter early background material has been included, but the major emphasis has been on the many recent advances that have been made. The early chapters of the book are concerned with the physical and chemical properties of riboflavin and its coenzyme derivatives and the nature of the interactions between flavoprotein apoenzymes and their coenzymes. The various methods currently available for measuring f1avins in biological tissues, particularly in man, have been described in detail, together with newer procedures that appear to have certain advantages over existing techniques. Chapters dealing with the absorption, excretion, and metabolism of riboflavin provide basic data on the processes involved in vitamin uptake and in metabolic transformations.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 434
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9781461344193
• Artikelnr.: 43993347

Inhaltsangabe

1 Physical and Chemical Properties of Flavins; Binding of Flavins to Protein and Conformational Effects; Biosynthesis of Riboflavin.- 1. Physical and Chemical Properties of Flavins.- 2. Effects of Flavin Cofactors on Nonprimary Protein Structure.- 3. Binding of Flavin Cofactors.- 4. Biosynthesis of Riboflavin.- 5. References.- 2 Analysis of Riboflavin and Its Derivatives in Biologic Fluids and Tissues.- 1. Introduction.- 2. Chemical Methods.- 3. Microbial Methods for Assay of Riboflavin.- 4. Comments and Clinical Applications.- 5. References.- 3 Chromatographic and Radioisotopic Methods for the Analysis of Riboflavin and the Flavin Coenzymes.- 1. Introduction.- 2. The Chromatographic Separation of Flavins.- 3. Radioisotopic Methods for the Study of 2?14C-Riboflavin Conversion to Flavin Coenzymes by Animal Tissues in Vivo or in Vitro.- 4. Competitive Protein Binding Assay of Riboflavin.- 5. References.- 4 Absorption, Protein Binding, and Elimination of Riboflavin.- 1. Absorption.- 2. Plasma Protein Binding.- 3. Elimination.- 4. General Pharmacology.- 5. References.- 5 Metabolism of Riboflavin.- 1. Tissue Uptake, Storage, and Distribution of Flavins and Flavin Coenzymes.- 2. Interconversions of Flavins, Flavin Glycosides, and Flavin Coenzymes.- 3. Excretion and Breakdown of Riboflavin.- 4. References.- 6 Nutritional Intake of Riboflavin.- 1. Historical Perspectives.- 2. Farming and Riboflavin Intake.- 3. Processing and Handling of Riboflavin Food Sources.- 4. Intake of Riboflavin.- 5. Recommendations for Improving Nutritional Intake.- 6. References.- 7 Riboflavin Deficiency.- 1. Riboflavin Deficiency in Animals.- 2. Metabolic Effects of Riboflavin Deficiency.- 3. Riboflavin Deficiency in Man.- 4. References.- 8 Experimental Dietary and Antagonist-Induced HumanRiboflavin Deficiency.- 1. Introduction.- 2. Dietary Induction of Deficiency.- 3. Antagonist-Induced Deficiency.- 4. Summary.- 5. References.- 9 Riboflavin Deficiency and Congenital Malformations.- 1. Introduction.- 2. Early Nutrition Experiments.- 3. Riboflavin Deficiency as a Teratogenic Method.- 4. Riboflavin Antimetabolites.- 5. Coenzyme and Enzyme Studies in Embryonal Tissues.- 6. Intrepretations.- 7. Summary.- 8. References.- 10 Biological Activities of Analogs of Riboflavin.- 1. General Background Information.- 2. Derivatives of Riboflavin.- 3. Isomers of Riboflavin.- 4. Homologs of Riboflavin.- 5. Analogs of Riboflavin.- 6. Biological Activity of Flavins in Other Systems.- 7. Structure-Activity Relationships.- 8. References.- 11 Riboflavin and Cancer.- 1. Introduction.- 2. Spontaneous and Transplanted Cancers.- 3. Chemical Carcinogenesis.- 4. Drug Metabolism in Cancer.- 5. Effects of Cancer on Tissue Flavin Levels.- 6. Summary and Conclusions.- 7. References.- 12 Hormonal Regulation of Riboflavin Metabolism.- 1. Introduction.- 2. Androgen and Estrogen.- 3. Insulin and Diabetes.- 4. Adrenal Hormones and ACTH.- 5. Thyroid.- 6. Summary and Conclusions.- 7. References.