RNA Polymerases as Molecular Motors (eBook, ePUB)

On the Road
Redaktion: Landick, Robert; Wang, Jue; Strick, Terence

• Format: ePub

Produktbeschreibung

To thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature's most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 252
• Erscheinungstermin: 23. November 2021
• Englisch
• ISBN-13: 9781839160660
• Artikelnr.: 63094727

Inhaltsangabe

A Structural Update
Initiation of Promoter Unwinding
Start-Site Selection and Promoter Escape
Small-molecule Inhibitors of Initiation: A Mechanistic Perspective
Nucleotide Addition, Fidelity, and Pausing
RNAP Transcription Through Barriers
Elongation Regulators
Termination and Antitermination
Global Regulation
Coupling to Molecular Motors
Transcription/Replication Conflicts
Transcriptional Bursting