RNA Therapeutics (eBook, ePUB)

The Evolving Landscape of RNA Therapeutics
Redaktion: Giangrande, Paloma H.; Rossi, John J.; de Franciscis, Vittorio

• Format: ePub

Produktbeschreibung

RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies.

Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development.

• Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies
• Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics
• Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 472
• Erscheinungstermin: 10. April 2022
• Englisch
• ISBN-13: 9780128217399
• Artikelnr.: 63739559

Inhaltsangabe

SECTION 1 The world of RNA therapeutics: Available RNA tools to modulate
cellular processes 1. Targeting chromatin: Transcriptional gene activation
(saRNA) 2. Argonaute and TNRC6, partners in RNAi 3. Targeted RNA
therapeutics for treatment of cancer and immunomodulation 4. Extrahepatic
delivery of RNA to immune cells
SECTION 2 Learning from history 5. Aptamer-based protein inhibitors 6.
Lessons learned from developing an oligonucleotide drug for a rare disease
SECTION 3 Delivery 7. Nucleoside modifications of in vitro transcribed mRNA
to reduce immunogenicity and improve translation of prophylactic and
therapeutic antigens 8. SOMAmer reagents and the SomaScan platform:
Chemically modified aptamers and their applications in therapeutics,
diagnostics, and proteomics
SECTION 4 From bench to bedside 9. CMC and regulatory aspects of
oligonucleotide therapeutics 10. CMC: Regulatory landscape 11. CMC and
manufacturing
SECTION 5 From bench to bedside 12. RNA delivery for cancer gene therapy
13. Combinatorial RNA therapies in cancer immunotherapy: Challenges and
directions