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SCHALM'S VETERINARY HEMATOLOGY An updated guide to veterinary hematology with expanded coverage on a variety of topics The revised seventh edition of Schalm's Veterinary Hematology is updated to provide a comprehensive review of all topics related to disorders of the blood in animals. Designed as a gold-standard reference, this text covers a wide range of species in both confined and free-range populations, reflects the most recent trends in hematology diagnostics, and discusses recent advances in traditional techniques. Edited and written by an international team of experts in the field, the…mehr
SCHALM'S VETERINARY HEMATOLOGY An updated guide to veterinary hematology with expanded coverage on a variety of topics The revised seventh edition of Schalm's Veterinary Hematology is updated to provide a comprehensive review of all topics related to disorders of the blood in animals. Designed as a gold-standard reference, this text covers a wide range of species in both confined and free-range populations, reflects the most recent trends in hematology diagnostics, and discusses recent advances in traditional techniques. Edited and written by an international team of experts in the field, the book represents an accessible yet in-depth resource for information on veterinary hematology. The new edition includes a hemolymphatic tissue section that covers current understanding of basic science and the species-specific hematology section is further expanded from previous editions. New chapters address emerging topics in hematology, and existing chapters have been revised and rearranged to improve readability and simplify access to the material. This seventh edition: * Updates the most complete reference on veterinary hematology across species * Contains a new section on basic biology of hemolymphatic tissues * Expands coverage of species-specific hematology * Presents new and emerging topics in blood disorders and diagnostic techniques * Features a reorganized contents list for an integrated, easy to use reference Written for veterinary clinical pathologists and residents, diagnostic laboratory staff, internists, and specialists, Schalm's Veterinary Hematology is the most comprehensive and up-to-date reference on the topic.
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The editors Marjory B. Brooks, DVM, DACVIM, is Director of the Comparative Coagulation Laboratory at Cornell University's Animal Health Diagnostic Center in Ithaca, New York, USA. Kendal E. Harr, DVM, MS, DACVP, is Owner and Clinical Pathologist at Urika, LLC in Mukilteo, Washington, USA. Davis M. Seelig, DVM, PhD, DACVP, is Associate Professor in the Department of Veterinary Clinical Sciences at the University of Minnesota College of Veterinary Medicine in St. Paul, Minnesota, USA. K. Jane Wardrop, DVM, MS, DACVP, is Professor in the Department of Veterinary Clinical Sciences at the College of Veterinary Medicine, Washington State University in Pullman, Washington, USA. Douglas J. Weiss, DVM, PhD, DACVP, is Emeritus Professor at the University of Minnesota College of Veterinary Medicine in St. Paul, Minnesota, USA.
Inhaltsangabe
Dedication v
Contributors xv
Preface xxv
Acknowledgments xxvii
Section I Hemolymphatic Tissue 1
Chapter 1 Embryonic and Fetal Hematopoiesis 3 Kelli L. Boyd and Brad Bolon
Chapter 2 Stem Cell Biology 9 Dori L. Borjesson and Jed A. Overmann
Chapter 3 Structure of the Bone Marrow 18 Nicole I. Stacy and John W. Harvey
Chapter 4 The Hematopoietic System 27 Bruce D. Car and Davis M. Seelig
Chapter 5 Vasculogenesis and Endothelial Cell Production 37 Jong Hyuk Kim
Chapter 6 Cluster of Differentiation (CD) Antigens 41 Melinda J. Wilkerson and Nora L. Springer
Chapter 7 Major Histocompatibility Complex Antigens 48 Paul R. Hess
Chapter 8 Lymphocyte Biology and Functions 63 Ian Tizard
Chapter 9 Structure and Function of Primary and Secondary Lymphoid Tissue 74 Cleverson D. Souza, Meredeth Mcentire, V.E. Ted Valli, and Robert M. Jacobs
Section II Hematotoxicity 85
Chapter 10 Design and Methods of Nonclinical Hematotoxicity Studies 87 William J. Reagan and Armando R. Irizarry Rovira
Chapter 11 Interpretation of Hematologic Data in Nonclinical Studies 93 JEFFREY Mccartney
Chapter 12 Nonclinical Evaluation of Compound-Related Cytopenias 100 Laurie G. O'rourke
Chapter 13 Nonclinical Evaluation of Compound-Related Alterations in Hemostasis 108 F. Poitout-Belissent
Chapter 14 Preclinical Evaluation of Immunotoxicity 116 Kristin L. Henson
Chapter 15 Blood and Bone Marrow Toxicity Induced by Drugs, Heavy Metals, Chemicals , and Toxic Plants 122 Douglas J. Weiss
Chapter 16 Acute Myelotoxicity and Myelitis in Domestic and Laboratory Animals 133 Adam D. Aulbach and Douglas J. Weiss
Chapter 17 Chronic Inflammation and Secondary Myelofibrosis in Domestic and Laboratory Animals 138 Adam D. Aulbach and Douglas J. Weiss
Chapter 18 Infectious Injury to Bone Marrow 144 K. Jane Wardrop
Chapter 1 Embryonic and Fetal Hematopoiesis 3 Kelli L. Boyd and Brad Bolon
Chapter 2 Stem Cell Biology 9 Dori L. Borjesson and Jed A. Overmann
Chapter 3 Structure of the Bone Marrow 18 Nicole I. Stacy and John W. Harvey
Chapter 4 The Hematopoietic System 27 Bruce D. Car and Davis M. Seelig
Chapter 5 Vasculogenesis and Endothelial Cell Production 37 Jong Hyuk Kim
Chapter 6 Cluster of Differentiation (CD) Antigens 41 Melinda J. Wilkerson and Nora L. Springer
Chapter 7 Major Histocompatibility Complex Antigens 48 Paul R. Hess
Chapter 8 Lymphocyte Biology and Functions 63 Ian Tizard
Chapter 9 Structure and Function of Primary and Secondary Lymphoid Tissue 74 Cleverson D. Souza, Meredeth Mcentire, V.E. Ted Valli, and Robert M. Jacobs
Section II Hematotoxicity 85
Chapter 10 Design and Methods of Nonclinical Hematotoxicity Studies 87 William J. Reagan and Armando R. Irizarry Rovira
Chapter 11 Interpretation of Hematologic Data in Nonclinical Studies 93 JEFFREY Mccartney
Chapter 12 Nonclinical Evaluation of Compound-Related Cytopenias 100 Laurie G. O'rourke
Chapter 13 Nonclinical Evaluation of Compound-Related Alterations in Hemostasis 108 F. Poitout-Belissent
Chapter 14 Preclinical Evaluation of Immunotoxicity 116 Kristin L. Henson
Chapter 15 Blood and Bone Marrow Toxicity Induced by Drugs, Heavy Metals, Chemicals , and Toxic Plants 122 Douglas J. Weiss
Chapter 16 Acute Myelotoxicity and Myelitis in Domestic and Laboratory Animals 133 Adam D. Aulbach and Douglas J. Weiss
Chapter 17 Chronic Inflammation and Secondary Myelofibrosis in Domestic and Laboratory Animals 138 Adam D. Aulbach and Douglas J. Weiss
Chapter 18 Infectious Injury to Bone Marrow 144 K. Jane Wardrop
