Science of Synthesis: C-1 Building Blocks in Organic Synthesis Vol. 2 (eBook, ePUB)

Alkenations, Cross Couplings, Insertions, Substitutions, and Halomethylations

• Format: ePub

Produktbeschreibung

The two-volume set on C-1 Building Blocks in Organic Synthesis critically reviews the state of the art of a wide variety of reactions by which one carbon atom is added to an organic molecule, forming a C-C bond. In spite of the numerous classic reactions of this kind, there has been enormous progress in recent years, especially for those reactions involving catalytic methods. Introduction of substituted methyl groups is a major challenge and only very recently the first catalysts have been discovered that enable the introduction of fluoromethyl groups in aromatics.

Produktdetails

• Verlag: Thieme
• Seitenzahl: 558
• Erscheinungstermin: 14. Mai 2014
• Englisch
• ISBN-13: 9783131765512
• Artikelnr.: 40308098

Inhaltsangabe

<p>2.1 C-1 Alkenation<br>2.1.1 Modern Variants of Wittig, Peterson, and Tebbe Protocols<br>2.2 C&#8212;C Cross Coupling<br>2.2.1 Cross-Coupling Methods for Methylation<br>2.2.2 Carbonylation of Aryl and Vinyl Halides<br>2.2.3 Cyanation of Aryl Halides<br>2.2.4 Oxidative Coupling of Nitromethane<br>2.3 Insertion into C&#8212;H Bonds<br>2.3.1 Carbene Insertion into C&#8212;H Bonds with C-1<br>2.4 Insertion into C&#8212;O and C&#8212;N Bonds<br>2.4.1 Carbon Monoxide Insertion into Epoxides and Oxetanes<br>2.4.2 Carbon Monoxide Insertion into Aziridines<br>2.5 Substitution Reactions<br>2.5.1 Hydroformylation of Epoxides<br>2.5.2 Cyanation of Epoxides<br>2.5.3 Cyanation of Aziridines<br>2.5.4 Carboxylation of Organometallic Reagents<br>2.5.5 Reaction of Formaldehyde with Organometallic Reagents<br>2.5.6 Mannich-Type Reactions<br>2.5.7 Formylation and the Vilsmeier Reagent<br>2.5.8 Metathesis Adding a C-1 Unit<br>2.6 Halomethylation<br>2.6.1 Trifluoromethylation<br>2.6.2 Difluoro- and Fluoromethylation<br>2.6.3 Karasch Reaction (Atom-Transfer Radical Addition Reactions)</p>