At the fourth Wiggers Bernard Conference, a group of 20 scientists from various fields discussed new findings relating to nitric oxide in shock, sepsis, and organ failure. It is now recognized that nitric oxide is induced by endotoxin and cytokines and plays a central role in infectious diseases, hemorrhage and ischemia. Intense discussions were held on the usefulness or danger of nitric oxide synthase inhibitors as well as on the application of exogenous nitric oxide or nitric oxide donors.
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