Sirtuin Biology in Cancer and Metabolic Disease (eBook, ePUB)

Cellular Pathways for Clinical Discovery
Redaktion: Maiese, Kenneth

• Format: ePub

Produktbeschreibung

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students.

• Chapters are authored by internationally recognized experts who elucidate the intimate relationship between cancer and metabolic disease that intersects with sirtuin pathways
• Presents the basic and clinical role of sirtuins in regard to cancer and metabolic disease
• Summarizes the multidiscipline views and publications for this exciting field of sirtuins for the development of new clinical treatments for cancer and metabolic disease
• Provides a vital foundation for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 300
• Erscheinungstermin: 20. Februar 2021
• Englisch
• ISBN-13: 9780128224847
• Artikelnr.: 61689240

Inhaltsangabe

Preface
Section I: Sirtuins and metabolic disease
1. Sirtuins in metabolic disease: innovative therapeutic strategies with
SIRT1, AMPK, mTOR, and nicotinamide
Kenneth Maiese
2. Sirtuins in metabolic and epigenetic regulation of stem cells
Yi Fang and Xiaoling Li
3. Sirtuins and metabolic regulation: food and supplementation
Sérgio Henrique Sousa Santos, Victor Hugo Dantas Guimarães, Janaina Ribeiro
Oliveira, and Luiz Fernando Rezende
4. Sirtuins in diabetes mellitus and diabetic kidney disease
Kultigin Turkmen
5. Sirtuins and mitochondrial dysfunction
Jian-Li He, Tian-Shi Wang, and Yi-Ping Wang
6. Sirtuins in immunometabolism
Hongxiu Yu
7. Mitochondrial sirtuins at the crossroads of energy metabolism and
oncogenic transformation
Maja Grabacka and Przemyslaw M. Plonka
Section II: Sirtuins and cancer
8. Sirtuins and the hallmarks of cancer
Talita H.B. Gomig, Tayana S. Jucoski, Erika P. Zambalde, Alexandre L.K.
Azevedo, Daniela F. Gradia, and Enilze M.S.F. Ribeiro
9. The bifunctional roles of sirtuins and their therapeutic potential in
cancer
Yeuan Ting Lee, Yi Jer Tan, Pei Yi Mok, Ayappav. Subramaniam, and Chern Ein
Oon
10. Sirtuins and next generation hallmarks of cancer: cellular energetics
and tumor promoting inflammation
Robert Kleszcz and Wanda Baer-Dubowska
11. Sirtuins and cellular metabolism in cancers
Zhen Dong and Hongjuan Cui
12. Dual role of sirtuins in cancer
Margalida Torrens-Mas and Pilar Roca
13. Sirtuin signaling in hematologic malignancies
Ryan A. Denu
14. Impacts of sirtuin1 and sirtuin3 on oral carcinogenesis
Shajedul Islam, Yoshihiro Abiko, Osamu Uehara, Yasuhiro Kuramitsu, and
Itsuo Chiba
Index