Skin Barrier (eBook, PDF)

Redaktion: Elias, Peter M.; Feingold, Kenneth R.

• Format: PDF

Produktbeschreibung

A must-have reference for any researcher or scientist interested in cutaneous protective mechanisms, this guide provides expertly researched chapters on every aspect of stratum corneum structure, function, and development, as well as detailed sections on barrier-repair strategies and the role of barrier function in diseases such as atopic dermatitis, psoriasis, and ichthyosis.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 632
• Erscheinungstermin: 22. September 2005
• Englisch
• ISBN-13: 9780849361296
• Artikelnr.: 53315716

Autorenporträt

Peter M. Elias, Kenneth R. Feingold

Inhaltsangabe

Introduction. Definitions and Broad Concepts. Integrative Aspects:
Protective Functions of the Stratum Corneum. History Overview. More
History: Evolution of the Barrier from Saran Wrap to Biosensor. Structure
of the Statum Corneum. Lipid Composition. SC Ceramides. Morphology of the
Stratum Corneum Barrier: Overview. Structure of the Stratum Corneum Lipid
Membranes. Cornified Envelope and Corneocyte-Lipid Envelope. Filaggrin.
Keratins. Corneodesmosomes. Tight Junctions and the Permeability Barrier.
Comparative Aspects of Barrier in Other Squamous Epithelia. Barrier
Function in Mucosal Epithelia. Dynamic Properties of the Stratum Corneum.
Stratum Corneum pH: Origin, Functions, and Measurement of the acid Mantle.
Lipid Processing: The Final Step in Barrier Formation. Desquamation.
Regulation of Stratum Corneum Formation. The Epidermal Lamellar Body as a
Multifunctional Secretory Organelle. Development of the Barrier in the
Fetus. Regulation of Barrier Function by Calcium. Cytokines: The Two-Edged
Sword. Nuclear Hormone Receptor 'Liposensors' Regulate Differentiation and
Barrier Formation. Functions of the SC. Maintenance of Permeability Barrier
Homeostasis. Defense from Mocrobial Invasion. The Epidermal Antioxidant
Barrier. Sources and Role of SC Hydration. Metabolism of Foreign
Substances: The Chemical Barrier. Vitamin D Formation and Function in
Barrier. Functional Abnormalities of the SC. Diseases that Affect Barrier
Function. Pathogenesis of Barrier Abnormalities in the Ichthyoses.
Pathogenesis of Desquamation and Permeability Barrier. Environmental
Occupational Disorders. The Aging Epidermal Barrier. Psychological Stress
and the Psychosensory Interface. Atopic Dermatitis. Epiologue