Skin Tissue Models (eBook, ePUB)

Redaktion: Marques, Alexandra P.; Cerqueira, Mariana; Pirraco, Rogério P.; Reis, DSc

• Format: ePub

Produktbeschreibung

Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury - from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology and emerging technologies.

The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates that can replace animal models.

• Offers descriptions of the normal structure/function of mammalian skin, exposure to clinical problems, and more
• Presents coverage of skin diseases (cancer, genodermatoses, vitiligo and psoriasis) that extends to clinical requirements and skin diseases in vitro models
• Addresses legal requirements and ethical concerns in drugs and cosmetics in vitro testing
• Edited and authored by internationally renowned group of researchers, presenting the broadest coverage possible

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 472
• Erscheinungstermin: 14. November 2017
• Englisch
• ISBN-13: 9780128110003
• Artikelnr.: 50212286

Autorenporträt

Alexandra Pinto Marques graduated in Biochemistry (1997) in the Faculty of Sciences of the University of Porto, Portugal, attended a one year specialisation course as part of the Biomedical Engineering Master/Doctoral Programme at the Faculty of Engineering of the University of Porto (1998) and obtained a PhD in Materials Science and Technology - Biomaterials in the University of Minho, Portugal and in cooperation with the University of Liverpool, UK (2004). She is Principal Investigator, a founder member and Vice-Director of the 3B's Research Group, a Research Unit of the University of Minho, Portugal, where she has been build her career in the field of skin tissue engineering. She has been integrating stem cells and biomaterials knowledge into tissue engineering as a way to define innovative strategies to improve the functionality of skin tissue engineered constructs. The establishment of in vitro 3D culture platforms to understand cellular crosstalk as well to be able to modul

ate the engineered constructs outcome has been the focus of her work. She has been awarded successive career grants among which a Consolidator Grant from the European Research Council (2016).

Rogério P. Pirraco (born 1982 Porto, Portugal) concluded his four year-graduation in Applied Biology in 2005, at the University of Minho and his PhD at the same university in 2011. During his PhD, he spent a total of one year at Professor Teruo Okano's Institute of Advanced Biomedical Engineering and Science of the Tokyo's Women Medical University in Tokyo, Japan, where he acquired knowledge in cell sheet engineering and its application in animal models. In 2016, Rogério got a 5 year FCT IF contract (career development grant from the Portuguese Science and Technology Agency) that will allow him to pursue his research interests in an independent way. Currently, his research interests are focused on the use of cell sheet engineering, stem cells and hypoxia for Tissue Engineering strategies.

Inhaltsangabe

Section 1 - Therapeutic Molecules and Cosmetics Testing1. Cosmetic industry requirements regarding skin models for cosmetic testing Christian Pellevoisin, Charbel Bouez, José Cotovio2. Overall perspective on the clinical importance of skin models Yusef Yousuf, Saeid Amini-Nik, Marc G. Jeschke,

Section 2 - Skin Diseases: clinical demands and diseased-skin in vitro models3. In vitro models of Melanoma Dagmar Kulms, Friedegund Meier4. Organotypic and humanized animal models of genodermatoses Esteban Chacón-Solan, Sara Guerrero-Aspizua, Lucía Martínez-Santamaría, Marcela Del Rio, Fernando Larcher5. In vitro models of Psoriasis Bryan Roy, Mélissa Simard, Isabelle Lorthois, Audrey Bélanger, Maxim Maheux, Alexandra Duque-Fernandez, Geneviève Rioux, Philippe Simard, Marianne Deslauriers, Louis-Charles Masson, Alexandre Morin and Roxane Pouliot6. In vitro models of VitiligoMuriel Cario-André, Katia Boniface, François-Xavier Bernard, Alain Taieb, Maria Lucia Dell'Anna, Julien Seneschal7. In vitro models of squamous cell carcinoma Elizabeth Pavez Loriè, Hans-Jürgen Stark, Manuel Berning, Petra Boukamp

Section 3 - Skin Substitutes: Clinical demands and skin tissue equivalents 8. Strategies to promote the vascularization of skin substitutes after transplantation Jennifer Bourland, Julie Fradette9. On the path to scarring-free skin regeneration approaches Mohammed Ashrafi, Adam Hague, Mohamed Baguneid, Teresa Alonso-Rasgado, Ardeshir Bayat10. Pre-clinical Models for Wound Healing Studies Irena Pastar, Liang Liang, Andrew P Sawaya, Tongyu Cao Wikramanayake, George D Glinos, Stephan Drakulich, Vivien Chen, Olivera Stojadinovic, Stephen C Davis, and Marjana Tomic-Canic 11. The importance of targeting inflammation in skin regeneration Megan Schrementi, Lin Chen, Luisa Ann DiPietro

Section 4 - In Vitro Models as study platforms of skin Biology12. In Vitro Models to study hair follicles generation Ana Korosec, Beate Maria Lichtenberger13. In Vitro Models to study cutaneous innervation mechanisms Nicolas Lebonvallet, Christelle Le Gall-Ianotto, Jérémy Chéret, Raphaël Leschiera, Matthieu Talagas, Raphaële Le Garrec, Virginie Buhé, Killian L'herondelle, Olivier Gouin, Mehdi Sakka, Nicholas Boulais, Ulysse Pereira, Jean-Luc Carré, Laurent Misery14. Skin in vitro models to study dermal white adipose tissue role in skin healing Manuela E. L. Lago, Mariana T. Cerqueira, Rogério P. Pirraco, Rui L. Reis, Alexandra P. Marques15. Immunocompetent in vitro skin models Victoria Hutter, Stewart B Kirton, David YS Chau

Section 5 - Emerging technologies for the development of 3D skin models16. Additive manufacturing in the development of 3D skin models Kelsey Retting, Deborah G. Nguyen 17. Induced Pluripotent Stem Cells Potential to generate skin tissue models Olga Kashpur, Avi Smith, Nailia Mukhamedshina, Jeremy Baskin, Yulia Shamis, Kyle Hewitt, Behzad Gerami-Naini, Jonathan A. Garlick18. Requirements of skin tissue models for high throughput screening Stephanie H. Mathes, Christian N. Parker