The field of computational systems biology emerged from the need to integrate multicomponent biological systems and explore the functional links among them. Through the combination of applied mathematics and bioscience, a quantitative description of intricate processes at subcellular, cellular and tissue levels can be offered in the form of computational models.
Aimed at postgraduate students and researchers in the fields of computational systems biology, applied mathematics and bioengineering, as well as medical practitioners, this book presents the physiology of various organs of the human body from the perspective of bioengineering. An emphasis is placed on the application of the theory of thin soft shells to simulate complex biomechanical events. The text begins by constructing multiscale biologically plausible models of the stomach, the small and large intestine, the gravid uterus, and the urinary bladder. Using these models, hidden and otherwise inaccessible physiological and pathophysiological mechanisms are investigated and an assessment of the effects of pharmacological modulations on their dynamics is offered.
Aimed at postgraduate students and researchers in the fields of computational systems biology, applied mathematics and bioengineering, as well as medical practitioners, this book presents the physiology of various organs of the human body from the perspective of bioengineering. An emphasis is placed on the application of the theory of thin soft shells to simulate complex biomechanical events. The text begins by constructing multiscale biologically plausible models of the stomach, the small and large intestine, the gravid uterus, and the urinary bladder. Using these models, hidden and otherwise inaccessible physiological and pathophysiological mechanisms are investigated and an assessment of the effects of pharmacological modulations on their dynamics is offered.
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