Soft Condensed Matter Physics in Molecular and Cell Biology (eBook, PDF)

Redaktion: Poon, W. C. K.; Andelman, David

• Format: PDF

Produktbeschreibung

The focus of Soft Condensed Matter Physics in Molecular and Cell Biology is based on the poignant realization that biology is soft matter come alive. The chapters in this volume originated as lectures in the NATO Advanced Science Institute and Scottish Universities Summer Schools in Physics. The book provides a thorough grounding in the fundamental nature and properties of soft matter, and then explores its application in biology, especially with regard to DNA investigations, and the study of protein behavior. The final section of the book considers experimental techniques, covering single molecule force spectroscopy of proteins, the use of optical tweezers, and solution scattering.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 344
• Erscheinungstermin: 13. Januar 2006
• Englisch
• ISBN-13: 9781420003338
• Artikelnr.: 53205907

Autorenporträt

W. C. K. Poon, D. Andelman

Inhaltsangabe

INTRODUCTION: Coarse graining in biological soft matter The atomistic
description of globular proteins: the tertiary structure Coarse-graining :
level 1 Secondary structure; Coarse-graining : level 2 Domains
Coarse-graining : level 3 Proteins as colloids Further coarse-graining I.
SOFT MATTER BACKGROUND Introduction to colloidal systems Colloidal phase
behaviour; Colloid dynamics The physics of floppy polymers Statistical
physics of single chains Statistical physics of many chains Polymer
dynamics Self-assembly and properties of lipid membranes The constituents
of lipid bilayer membranes Self assembly Bilayer membrane phases Membrane
energies Fluctuations Domains, shapes and other current issues Some aspects
of membrane elasticity Gibbs' description Description in terms of
microscopic properties Equations of equilibrium and shape of interfaces
Introduction to electrostatics in soft and biological matter The
Poisson-Boltzmann theory Poisson-Boltzmann equation: planar geometry;
Poisson-Boltzmann equation: cylindrical coordinates; Poisson-Boltzmann
equation: spherical coordinates -- Charged colloids Beyond the
Poisson-Boltzmann treatment Thermal Barrier Hopping in Biological Physics A
preliminary: Diffusion on a flat landscape First passage times: an exact
result Landscapes and intermediate states Higher-dimensional barrier
crossing II. BIOLOGICAL APPLICATIONS Elasticity and dynamics of
cytoskeletal filaments and their networks Single-filament properties
Solutions of semi-flexible polymer Network elasticity Nonlinear response
Twisting and stretching DNA: Single-molecule studies Micromanipulation
techniques Stretching DNA DNA under torsion DNA-protein interactions
Interactions and conformational fluctuations in DNA arrays Electrostatic
interactions Equation of state: No thermal fluctuations; Effect of thermal
fluctuations (1) Effect of thermal fluctuations (2) Sequence-structure
relationships in proteins Energy functions for fold recognition The
evolutionary capacity of