Spatially Fractionated, Microbeam and FLASH Radiation Therapy (eBook, ePUB)

A physics and multi-disciplinary approach
Redaktion: Zhang, Hualin; Mayr, Nina

• Format: ePub

Produktbeschreibung

The limits of radiation tolerance of normal tissues, which often deter the use of sufficiently large doses to the tumor, have been a persistent challenge in the treatment of bulky primary and metastatic cancers. A novel technique of heterogeneous irradiation using spatial intensity modulation of megavoltage therapy beams, commonly referred to as Spatially Fractionated Radiation Therapy (SFRT) has shown promise in clinical patients with bulky advanced tumors, leading to increasing clinical use. Meanwhile, FLASH therapy, a novel radiation therapy technique employing ultra-high dose-rate, was recently used for the first time in human and continues to be investigated.

This textbook is a comprehensive text of the physics of heterogeneous radiation, and is linked, in a multidisciplinary approach, to its clinical applications and biological considerations of heterogenous radiation. The book addresses fundamental principles SFRT, techniques and technologies of SFRT, including GRID and Lattice radiotherapy, dosimetric properties, planning methods, documentation and standardized reporting metrics for SFRT, and clinical practice recommendations. The current status and results of clinical patient studies are presented, which have the potential to advance the clinical management of bulky and advanced tumors through improved treatment response. Practical clinical applications and procedures related to SFRT technologies are incorporated where appropriate. Potential biological underpinnings are reviewed, which may challenge the current radiobiological understanding of radiation response models and parameters of radiation therapy design. The current status of Flash therapy is discussed in its clinical and biological context. Microbeam radiation therapy and Minibeam proton technology that have recently emerged, leveraging rapid developments of synchrotron technologies are reviewed.

The purpose of this book is to provide advanced understanding of GRID therapy, Lattice therapy, Microbeam, Minibeam and Flash radiation therapy, from their physics foundations, as well as the multidisciplinary context of underpinning biology, which is intrinsically linked to clinical response; and the essential context of the clinical applications.
This book is an essential text for practitioners and researchers and in the fields of medical physics, radiation oncology and related sciences.

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Produktdetails

• Verlag: Institute of Physics Publishing
• Seitenzahl: 250
• Erscheinungstermin: 29. Juni 2023
• Englisch
• ISBN-13: 9780750340465
• Artikelnr.: 68370121