Stearoyl-CoA Desaturase Genes in Lipid Metabolism (eBook, PDF)

Redaktion: Ntambi, Ph. D.

• Format: PDF

Produktbeschreibung

James Ntambi has gathered top authors to write about the remarkable growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species including human. The book shows that beginning with simple cellular models of differentiation a broad and comprehensive analysis of the SCD gene family in a number of species and biological systems has been carried out over the course of the last twenty five years. SCD is a central enzyme in lipid metabolism that synthesizes monounsaturated fatty acids (MUFA) from saturated fatty acid precursors. At first glance, SCD would be considered a housekeeping enzyme because its product oleate is a well-known MUFA that is abundant in many dietary sources and tissue lipids.

A particular highlight in the chapters of the book is that MUFAs may have signaling properties that regulate metabolism. For example, a proper ratio of saturated to MUFA contributes to membrane fluidity, and oleate has also been implicated as a mediator of signal transduction, cellular differentiation and metabolic homeostasis. It is also highlighted that SCD-1 repression mediates the metabolic effects of the hormone leptin. Conditional alleles and corresponding tissue-specific knockout mouse models for many of the SCD gene isorfms have provided a wealth of information on not only tissue-specific fatty acid metabolism but also the key transcription factors that regulate SCD expression under a variety of metabolic and genetic backgrounds. The studies described indicate that control of SCD expression occurs via a series of complex signal transduction schemes making SCD one of the most highly studied lipogenic gene families to date.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 239
• Erscheinungstermin: 15. August 2013
• Englisch
• ISBN-13: 9781461479697
• Artikelnr.: 43799554

Inhaltsangabe

SCD genes of fatty acid synthesis.- SCD genes in heart metabolism.- SCD genes in liver metabolism.- SCD genes in harderian and perpetual glands.- SCD genes In lipogenesis.- SCD genes lipoproteins.- SCD genes in WAT.- SCD genes in muscle.- SCD genes in the brain.- SCD genes in inflammation.- SCD genes in ER Stress.- SCD genes in skin.- SCD genes in insulin signaling.- SCD genes in thermogenesis.- SCD genes in diabetes.- SCD genes atherosclerosis.- SCD genes in Adipocyte differentiation.- SCD genes and epigenetics.- SCD genes in fatty liver disease.- SCD genes in Colitis.- SCD genes in leptin signaling.