Maxwell Bennett, Jim Lagopoulos

Stress, Trauma and Synaptic Plasticity (eBook, PDF)

• Format: PDF

Produktbeschreibung

This book provides detailed insights into the cellular and molecular alterations that occur in the brain following stress and trauma.

The changes to the grey matter in certain areas of the brain are similar in stressed humans and animals, with the most likely basis for these changes being the degeneration of synaptic connections. In the book's initial sections, the reader will learn about the core network of synaptic connections that are affected by stress and trauma disorders. These connections are chiefly modulated by dopamine, serotonin and Brain Derived Neurotrophic Factor (BDNF). In subsequent chapters, the NMDA-receptor-mediated plasticity of these synapses is discussed,with particular attention paid to how glucocorticoids can interfere with the function of BDNF and thereby affect the synapse's physical stability. The book concludes by integrating the observations made in the previous sections so as to present plausible hypotheses regarding the identity of the networks, synapses and molecular pathways that promote fear and extinction.

Providing an up-to-date overview of the mechanisms of synaptic plasticity and physiological changes in the stressed and traumatized brain, this book will appeal to researchers, clinicians and students in the neurosciences.

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Produktdetails

• Verlag: Springer Nature Switzerland
• Seitenzahl: 231
• Erscheinungstermin: 1. Februar 2019
• Englisch
• ISBN-13: 9783319911168
• Artikelnr.: 55100253

Autorenporträt

M. R. Bennett AO is an internationally renowned neuroscientist. He is a professor of Neuroscience & University Chair at the University of Sydney, the founding director of the 'Brain and Mind Research Institute' and has been the president and organizer of many societies and symposia. His research has led to groundbreaking revelations in understanding synaptic functioning. He is the author of numerous papers and books, including 'Philosophical Foundations of Neuroscience' (2003 with Peter Hacker) and the recent works 'Virginia Woolf and Neuropsychiatry' (2013), 'History of Cognitive Neuroscience (2008 with Peter Hacker) and 'Neuroscience and Philosophy: Brain, Mind and Language (2006 with Daniel Dennett, John Searle and Peter Hacker). Prof. Bennett has received the leading award in biology and medicine in Australia (the Macfarlane Burnet Medal) as well as being made an 'Office of the Order of Australia' for his outstanding 'service to the biological sciences, particularly in the field of neurosciences'.

Professor J. Lagopoulos is the inaugural director of the Sunshine Coast Mind and Neuroscience - Thompson Institute, which focuses on mental health and neurological research, clinical services and teaching. He is an expert in magnetic resonance imaging (MRI) and has been involved in neuroimaging for over 20 years. His work focuses on youth mental health, post-traumatic stress disorders and traumatic brain injury. Prof. Lagopoulos is a leading academic and imaging specialist who has published more than 180 peer-reviewed papers and contributed to several books. He is member of numerous international societies, including the 'International Society for Magnetic Resonance in Medicine' and the 'Organization of Human Brain Mapping'. He has received numerous awards, including a NARSAD independent investigator award.

Inhaltsangabe

Grey matter changes in the brain following stress and trauma.- Synaptic changes responsible for grey matter changes in the brain of animal models following stress.- Identification of the core neural network subserving PTSD in animal models and their modulation.- Modulation of the core neural network in stress: the role of Brain Derived Neurotrophic Factor & LTP.- Modulation of the core neural network in stress: the role of Endocannabinoids & LTD.- Functioning of the core neural network in fear and extinction.- Modulation of the core synaptic network in extinction: the role of Brain Derived Neurotrophic Factor.- Appendix 1: F-actin determination of dendritic spine integrity.- Appendix 2: Regulation of NMDA receptors.