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Master's Thesis from the year 2009 in the subject Medicine - Pharmacology, Pharmacy, grade: 1, , course: Pharmaceutical Sciences, language: English, abstract: Piper nigrum is one amongst the thousands of the plants which have been bestowed with rich medicinal values.The work has been done to explore the therapeutic potential of piperine from Piper nigrum and synthesize of some piperine analogues. The work has been planned to carry out detailed phytochemical studies to isolate and characterize the main alkaloidal phytoconstituents i.e. piperine present in the methanolic extract. The basis of selection of piperine is its CNS depressant activity and to expect the synthesis of some potent CNS Depressants derived from piperine after isoloation. Further, the piperine and its semi-synthetic analogues have been screened for its CNS Depressants activity.