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  • Format: ePub

Surface plasmon resonance biosensors, ellipsometry biosensors, resonant mirror biosensors, and interferometry biosensors are optical instruments used to detect ligand-receptor interactions in biological research, clinical diagnoses and in the pharmaceutical industry. However, they are not sensitive enough for samples with molecular weight less than a few kilo-Daltons. The hybridization of surface plasmon resonance and ellipsometry makes it possible to build a super biosensor which can be used to detect samples with small molecules of less than a few hundred Daltons. The structure and…mehr

Produktbeschreibung
Surface plasmon resonance biosensors, ellipsometry biosensors, resonant mirror biosensors, and interferometry biosensors are optical instruments used to detect ligand-receptor interactions in biological research, clinical diagnoses and in the pharmaceutical industry. However, they are not sensitive enough for samples with molecular weight less than a few kilo-Daltons. The hybridization of surface plasmon resonance and ellipsometry makes it possible to build a super biosensor which can be used to detect samples with small molecules of less than a few hundred Daltons. The structure and operations of such hybrid biosensor increases the complexity and difficulty of operation, requiring a greater understanding of their workings in order to maximise their efficiency.

Commencing by defining a set of standards for benchmarking sensors to enable better comparison, this book then proceeds to provide a review of the physics and workings of several optical biosensors, and introduces two more super optical biosensors, including the most sensitive super optical biosensor 'RMEPA', an abbreviation of three optical technique names: resonant mirroring, ellipsometry and attenuated total reflection. Mathcad is used to analyse these biosensors and these codes are available to readers for use in their own research. It will be a key reference for researchers in academia and industry, particularly those involved in developing next generation optical biosensors.


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Autorenporträt
Caide Xiao obtained his bachelor's degree in physics from Central China Normal University and was a lecturer of medical physics in Yunyang University. Following his PhD in optical biosensors from Tsinghua University he has subsequently been a research fellow and visiting scholar at the Biotechnology Research Institute in Montreal, Oakland University in Rochester, West Virginia University and the University of Calgary.